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Acetaminophen/Caffeine, Oral a-seet-a-MIN-oh-fen ka-FEEN

What are other names for this medicine?

Type of medicine: analgesic (painkiller)

Generic and brand names: acetaminophen/caffeine, oral; Excedrin QuickTabs; Excedrin Tension Headache (There may be other brand names for this medicine.)

What is this medicine used for?

This medicine is taken by mouth to relieve pain and reduce fever.

What should my healthcare provider know before I take this medicine?

To avoid the risk of taking an overdose, tell your provider or pharmacist about all of the other medicines you take. This includes nonprescription products.

Many prescription and nonprescription medicines for pain, headache, and sinus congestion contain acetaminophen. Read the labels of nonprescription products to find out which may contain acetaminophen. If you cannot tell if you are taking more than the recommended dosage per day, ask your healthcare provider and pharmacist to review all of your medicines.

Tell your healthcare provider if you have ever had an allergic reaction to any medicine. Check with your healthcare provider before taking this medicine if you have:

  • liver or kidney disease

Females of childbearing age: Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I use it?

Take this medicine exactly as your healthcare provider prescribes. Do not take more of it or take it longer than directed. Taking too much may cause liver damage. If you purchased this medicine without a prescription, follow the directions on the package. Read all of the precautions and warnings printed on the package.

Take the medicine with a full glass of water. You may take this medicine with or without food. Taking it with meals may lessen the chance the drug will upset your stomach.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: ringing in the ears, headache, confusion, restlessness, trouble sleeping, tremors, hallucinations, nausea, vomiting, low fever, loss of appetite, dark urine, yellowing of the skin or eyes, sweating, seizures, coma.

What should I watch out for?

This medicine may cause severe liver damage if:

  • an adult takes more than 4000 mg in 24 hours
  • a child takes more than 5 doses in 24 hours
  • You take this medicine with other drugs that contain acetaminophen
  • an adult has 3 or more alcoholic drinks every day while using this product

Contact your healthcare provider if you take this medicine for fever and it gets worse or does not improve in 3 days. If you take this medicine for pain and it does not improve in 10 days, contact your healthcare provider.

Alcohol may increase the chance of liver damage by this medicine. Do not drink alcohol while taking this medicine. Ask your healthcare provider about this.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Yellowish eyes or skin; rash; hives; itching; bloody or cloudy urine; trouble urinating; fainting; weakness; sore throat; fever; unusual bleeding or bruising; dark urine; light-colored bowel movements; severe stomach pain; ringing in the ears or hearing loses; severe nausea or vomiting.

Other: Heartburn, nervousness.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • cholestyramine (Questran) (Take this medicine 1 hour after or 4 hours before taking other medicines.)
  • MAO inhibitor antidepressants such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam), and tranylcypromine (Parnate) (Do not take this medicine and an MAO inhibitor within 14 days of each other.)
  • stimulants such as amphetamine/dextroamphetamine, caffeine (coffee, cola, tea), diet pills, dextroamphetamine (Dexedrine), methylphenidate (Ritalin), and some cough and cold medicines such as pseudoephedrine (Sudafed, Neo-Synephrine)
  • warfarin (Coumadin)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-09-09
Last reviewed: 2011-01-14
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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