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Acrivastine/Pseudoephedrine, Oral AK-ri-vas-teen soo-doh-e-FED-rin

What are other names for this medicine?

Type of medicine: antihistamine; decongestant

Generic and brand names: acrivastine and pseudoephedrine, oral; Semprex-D

What is this medicine used for?

This medicine contains both an antihistamine and a decongestant. It is taken by mouth to treat the symptoms of colds, hay fever, and sinus problems.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergy to any medicine
  • an enlarged prostate gland or trouble urinating
  • a lung disease such as asthma or COPD
  • a peptic (stomach) ulcer
  • a stroke
  • diabetes
  • glaucoma
  • heart or blood vessel disease
  • high blood pressure
  • kidney or liver disease
  • Parkinson's disease
  • seizures
  • thyroid disease

Do not take this medicine if you have taken an MAO inhibitor within the last 14 days. Using these products together can cause very serious side effects.

Phenylketonurics: Talk with your healthcare provider. Some products contain phenylalanine.

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes. If your healthcare provider has not given you specific instructions, follow the directions that come with the medicine package. Do not take more or take it longer than prescribed. Ask your healthcare provider or pharmacist about anything you do not understand.

This medicine may come in different forms. If you have extended-release tablets, do not break, crush, or chew them. Swallow them whole. Ask your pharmacist if you have the extended-release tablets. If you have the liquid form of this medicine, use a special dose-measuring spoon or medicine cup to measure the correct dose.

The decongestant in this medicine can cause you to feel nervous or have trouble sleeping. Taking the last dose of the day before 6 PM may help.

You may take this medicine with food or milk to lessen the chance that it may upset your stomach.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: nausea, vomiting, seizures, fast or irregular heartbeat, restlessness, fever, trouble breathing, drowsiness.

What should I watch out for?

Do not give a child under age 6 any cough and cold medicines unless specifically instructed to do so by your healthcare provider. Talk with your healthcare provider about this.

Adults over the age of 65 may be at greater risk for side effects. Talk with your provider about this.

This medicine may make you drowsy. Do not drive or operate machinery unless you are fully alert.

This medicine increases the effects of alcohol and other drugs that slow down the central nervous system. Do not drink alcohol or take other medicines unless your healthcare provider approves.

This medicine may increase the effects of some diet medicines. Do not take any diet medicines unless your healthcare provider approves.

If your symptoms do not improve within 7 days or if they get worse, contact your healthcare provider.

If you need emergency care or surgery, tell the healthcare provider you are taking this medicine.

This medicine may cause dry eyes, especially if you wear contacts. Talk with your provider about this.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Irregular heartbeat, extreme tiredness, weakness, clumsiness, trouble urinating, confusion, hallucinations, vision problems, muscle spasms or twitching.

Other: Drowsiness, dizziness, heavier phlegm, nervousness, dry eyes, dry mouth, headache, diarrhea, trouble sleeping, flushing.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • beta blockers such as acebutolol (Sectral), atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), pindolol, propranolol (Inderal), and sotalol (Betapace)
  • bromocriptine (Cycloset)
  • calcium channel blockers such as diltiazem (Cardizem, felodipine, isradipine (DynaCirc CR), nicardipine (Cardene), nifedipine (Adalat CC, Procardia), and verapamil (Calan, Covera-HS, Isoptin SR, Verelan, Tiazac)
  • linezolid (Zyvox)
  • MAO inhibitor antidepressants such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam), and tranylcypromine (Parnate) (Do not take this medicine and an MAO inhibitor within 14 days of each other.)
  • methyldopa
  • muscle relaxants such as baclofen (Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), dantrolene (Dantrium), methocarbamol (Robaxin), and tizanidine (Zanaflex)
  • natural remedies such as capsicum, chamomile, ephedra, ginseng, goldenseal, gotu kola, kava, lemon balm, sage, sassafras, valerian, and yohimbe
  • narcotic pain medicines such as codeine, fentanyl (Duragesic, Actiq), hydrocodone/acetaminophen (Vicodin), hydromorphone (Dilaudid), meperidine (Demerol), morphine (Kadian, MS Contin), oxycodone (OxyContin, Roxicodone), and oxycodone/acetaminophen (Percocet)
  • other allergy, cough, or cold medicines that contain an antihistamine or decongestant
  • phenytoin (Dilantin)
  • procarbazine (Matulane)
  • sedatives such as amobarbital (Amytal), butabarbital (Butisol), phenobarbital, triazolam (Halcion), zaleplon (Sonata), and zolpidem (Ambien)
  • selegiline (Eldepryl)
  • stimulants such as amphetamine/dextroamphetamine (Adderall), methylphenidate (Ritalin), modafinil (Provigil) and diet pills
  • tranquilizers such as alprazolam (Xanax), chlordiazepoxide (Librium), diazepam (Valium), lorazepam (Ativan), and meprobamate (Equanil)

Do not drink alcohol while you are taking this medicine

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-02-18
Last reviewed: 2010-11-22
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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