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Belladonna Alkaloids/Phenobarbital, Oral bel-a-DON-a AL-ka-loydz fee-noh-BAR-bi-tal

What are other names for this medicine?

Type of medicine: antispasmodic; anticholinergic

Generic and brand names: belladonna alkaloids and phenobarbital, oral; Donnatal; hyoscyamine, atropine, scopolamine, and phenobarbital, oral; Donnatal Elixir; Donnatal Extentabs; Servira

What is this medicine used for?

This medicine is a combination product taken by mouth to treat cramps or spasms in your stomach and intestines due to conditions such as irritable bowel syndrome. It may also be used to treat duodenal ulcers. It may be used with other medicines.

It may be used for other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • a blockage in the gastrointestinal system or urinary tract
  • a muscle disease such as myasthenia gravis
  • an enlarged prostate gland
  • an overactive thyroid
  • asthma or other long term lung disease
  • glaucoma
  • heart problems such as heart failure, or a fast or irregular heartbeat
  • hiatal hernia
  • high blood pressure
  • kidney or liver disease
  • porphyria (chemical imbalance that can affect the nerves and skin)
  • problems with substance abuse
  • severe ulcerative colitis
  • trouble swallowing or reflux disease

Females of childbearing age: Talk with your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as directed by your healthcare provider. Do not take more of it or take it longer than directed. Do not stop taking this medicine without your healthcare provider's approval. You may have to reduce your dosage gradually.

This medicine works best when taken 30 to 60 minutes before meals.

This medicine may come in different forms. If you have extended-release tablets, do not break, crush, or chew them. Swallow them whole. Ask your pharmacist if you have the extended-release tablets.

If you have the liquid form of this medicine, use a special measuring spoon rather than a common kitchen spoon to make sure you are getting the right dose.

If you are taking antacids, take them 1 hour before or 2 hours after you take this medicine.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: headache, nausea, vomiting, dry mouth, restlessness, flushing, trouble swallowing, blurred vision, large pupils, hot dry skin, dizziness, drowsiness, confusion, anxiety, seizures, irregular heartbeat.

What should I watch out for?

This medicine increases the effects of alcohol and other drugs that slow down the nervous system. Do not drink alcohol or take other medicines unless your healthcare provider approves.

You may sweat less while you are taking this medicine. Avoid extreme heat, saunas, hot tubs, and exercising too much. You can overheat which can cause heat stroke.

This medicine may make your eyes more sensitive to light. Wearing sunglasses will help decrease your discomfort.

This medicine may cause dry eyes and make contact lenses uncomfortable. Lubricating eyedrops may help.

Adults over the age of 65 may be at greater risk for side effects such as nervousness or drowsiness. Talk to your healthcare provider about this.

This medicine may cause drowsiness, dizziness, or blurred vision. Do not drive or operate machinery unless you are fully alert and can see clearly.

Dry mouth is a common side effect of this medicine. If it continues or gets worse, tell your healthcare provider. It is important to drink plenty of water while you are taking this medicine.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat); seizures.

Serious (report these to your healthcare provider right away): Severe vision problems or eye pain, confusion, clumsiness, slurred speech, hallucinations, muscle weakness, fast or irregular heartbeat, flushing, diarrhea, trouble urinating, high or low blood pressure.

Other: Constipation, dry mouth, decreased sweating, nausea, vomiting, change in taste, stuffy nose, restlessness, drowsiness, mild dizziness, headache, dilated pupils, blurred vision, trouble sleeping, muscle pain, change in sexual ability or desire.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Also, using these medicines together might cause harmful side effects. Talk to your healthcare provider if you are taking any of these medicines:

  • acetaminophen (Tylenol)
  • amantadine (Symmetrel)
  • antacids such as Maalox, Mylanta, Amphojel, and Tums (take them 2 hours apart from this medicine)
  • antiarrhythmics (medicines to treat irregular heartbeat) such as amiodarone (Cordarone), quinidine (quinidine sulfate, quinidine gluconate), and propafenone (Rythmol)
  • antibiotics such as rifampin (Rifadin, Rimactane), chloramphenicol (Chloromycetin), doxycycline (Adoxa, Doryx, Monodox, Vibramycin), and rifabutin (Mycobutin)
  • anticholinergic medicines such as atropine sulfate, benztropine (Cogentin), dicyclomine (Bentyl), hyoscyamine (Levsin), methscopolamine (Pamine), propantheline, and trihexyphenidyl
  • antidepressants such as amitriptyline, bupropion (Wellbutrin), desipramine (Norpramin), doxepin, duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox CR), imipramine (Tofranil), nefazodone, nortriptyline (Pamelor), paroxetine (Paxil), sertraline (Zoloft), trazodone, and venlafaxine (Effexor)
  • antihistamines such as diphenhydramine (Benadryl), hydroxyzine (Vistaril), meclizine (Antivert, Dramamine), and chlorpheniramine (Chlor-Trimeton)
  • anti-HIV medicines such as delavirdine (Rescriptor), efavirenz (Sustiva), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), and saquinavir (Invirase)
  • antipsychotic medicines such as chlorpromazine, fluphenazine, olanzapine (Zyprexa), prochlorperazine, risperidone (Risperdal), quetiapine (Seroquel), thioridazine, and ziprasidone (Geodon)
  • antianxiety medicines such as alprazolam (Xanax), clonazepam (Klonopin), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), and oxazepam
  • antiseizure medicines such as carbamazepine (Tegretol), felbamate (Felbatol), lamotrigine (Lamictal), phenytoin (Dilantin), and topiramate (Topamax)
  • barbiturates such as amobarbital, mephobarbital, pentobarbital (Nembutal), phenobarbital, and secobarbital (Seconal)
  • beta blockers such as atenolol (Tenormin), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal)
  • calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem), nifedipine (Adalat, Procardia), isradipine (DynaCirc), felodipine (Plendil), verapamil (Calan, Isoptin), and nicardipine (Cardene)
  • corticosteroids such as betamethasone (Celestone), cortisone, dexamethasone, fludrocortisone (Florinef), hydrocortisone (Cortef), methylprednisolone (Medrol), prednisolone (Orapred), prednisone, and triamcinolone (Aristospan, Kenalog)
  • digoxin (Lanoxin)
  • hormonal birth control such as pills, implants, shots, patches, or vaginal rings
  • immunosuppressants such as cyclosporine (Sandimmune, Gengraf, Neoral), sirolimus (Rapamune), and tacrolimus (Prograf, Protopic)
  • medicines used to treat diarrhea such as Kaopectate and Pepto-Bismol (take them 2 hours apart from this medicine)
  • muscle relaxants such as baclofen (Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), dantrolene (Dantrium), methocarbamol (Robaxin), and tizanidine (Zanaflex)
  • narcotic pain medicines such as codeine, fentanyl (Duragesic, Actiq), hydrocodone/acetaminophen (Vicodin, Lortab), hydromorphone (Dilaudid), meperidine (Demerol), methadone (Dolophine), morphine (Kadian, MS Contin), oxycodone (OxyContin, Roxicodone), oxycodone/acetaminophen (Percocet, Tylox), and pentazocine (Talwin)
  • natural remedies such as gotu kola, kava, St. John's wort, and valerian
  • sleeping pills such as flurazepam, phenobarbital, temazepam (Restoril), triazolam (Halcion), zaleplon (Sonata), and zolpidem (Ambien)
  • theophylline
  • warfarin (Coumadin)

Do not drink alcohol while taking this medicine.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-06-30
Last reviewed: 2011-01-25
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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