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Drospirenone/Estradiol, Oral droh-SPY-re-none es-tra-DY-ole

What are other names for this medicine?

Type of medicine: hormone

Generic and brand names: estradiol and drospirenone, oral; Angeliq

What is this medicine used for?

This medicine is taken by mouth to replace hormone levels that drop when menopause occurs (when monthly menstrual periods stop). It contains two kinds of hormones, progestin and estrogen. It helps with symptoms such as hot flashes and vaginal dryness, itching, and burning.

This medicine is taken by women who still have a uterus. This medicine should not be used by women who have had a hysterectomy (surgery to remove the uterus).

It may be used for other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Tell your healthcare provider if you have ever had:

  • an allergic reaction to any hormones or medicines
  • a heart attack or stroke
  • a hysterectomy (removal of the uterus)
  • adrenal gland disease
  • asthma
  • blood clots in your legs, lungs, brain, or eyes
  • cancer of the breast, uterus, cervix, or vagina
  • depression
  • diabetes
  • endometriosis
  • heart, liver, gallbladder, or kidney disease
  • high blood pressure
  • high cholesterol
  • lupus
  • migraines or headaches along with vomiting, double vision, unsteadiness, weakness, or personality changes
  • porphyria (nerve pain or sensitivity to sunlight)
  • problems with calcium, potassium, or sodium levels in the blood
  • seizures
  • thyroid disease
  • unexplained vaginal bleeding
  • yellowing of the eyes or skin (jaundice) during pregnancy or during past use of birth control pills

Tell your healthcare provider if you have recently had a long period of bed rest after major surgery or a broken bone in a cast.

Tell your provider if you have a family history of heart disease, heart attack, blood clots, strokes, breast cancer, or other conditions.

Tell your healthcare provider if you smoke. Smoking while you are using this medicine increases the risk of serious side effects such as heart attack, stroke, and blood clots. The risk increases with age and the number of cigarettes smoked a day. Talk to your healthcare provider about ways to quit smoking.

Females of childbearing age: Do not take this medicine during pregnancy because it may harm the baby. Tell your healthcare provider if think you are pregnant or plan to become pregnant while taking this medicine. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I use it?

Check the label on the medicine for directions about your specific dose. Follow your healthcare provider's directions exactly. To help you remember to take your daily dose, try to take the tablets at the same time each day.

Read the information sheet that comes in the medicine package. Follow these directions carefully. If you do not understand how to use this medicine, ask your healthcare provider or pharmacist to explain.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: nausea.

What should I watch out for?

Hormone therapy, also known as hormone replacement therapy (HRT) offers both benefits and risks. Estrogen has previously been prescribed to help prevent bone loss (osteoporosis). This is no longer advised because it may be harmful. Combined estrogen/progestin therapy may reduce the risk of colorectal cancer. However, estrogen/progestin therapy increases the risk of heart disease, stroke, breast cancer, blood clots in the lungs and legs, gallbladder disease, and possibly dementia.

Most experts now recommend short-term use if hormone therapy is needed. You should take hormones only when you need them, at the lowest effective dosage, and only for as long as you need them. The risk of medical problems such as stroke or cancer increases further with higher doses and longer treatments. Talk with your healthcare provider about this.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine. You may need to stop taking hormones at least 4 to 6 weeks before the surgery and bedrest. Tell healthcare providers you are taking this medicine before you have lab tests. This medicine may change blood test results such as cholesterol, liver function, and thyroid levels.

You need to see your provider regularly (every 6 months) for checkups to find out if this medicine is still needed and if you are having any side effects. This medicine may increase the potassium levels in your blood. You may need to have blood tests regularly to see how this medicine affects you. Keep all your appointments. Do not take this medicine for longer than 1 year without a complete physical exam.

Sometimes this medicine causes dark spots to develop on your skin, especially with long exposure to the sun. The spots usually go away when you stop using this medicine. While you are taking this medicine, avoid long exposure to the sun. Wear protective clothing, a hat, and sunscreen lotion when you need to be outdoors. Do not use a sunlamp.

If you wear contact lenses and notice a change in your vision or it becomes difficult to wear your lenses, contact your healthcare provider.

This medicine may increase your HDL cholesterol levels, decrease your LDL levels, and increase your blood triglyceride levels. Talk to your healthcare provider about this.

Diabetics: This medicine may affect your blood sugar level and change the amount of insulin or other diabetes medicines you may need. Talk to your healthcare provider about this.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you are unable to reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives, itching, rash, trouble breathing, swelling of your lips, tongue and throat); sudden, severe headache; sudden, severe vomiting; sudden partial or complete loss of vision; sudden dizziness or fainting; speech problems; weakness or numbness of an arm or a leg; crushing chest pain or chest heaviness; coughing up blood; sudden shortness of breath; swelling.

Serious (report these to your healthcare provider right away): Unexplained bleeding from your vagina; dizziness; fainting; breast lumps; redness, warmth, or swelling in your hands, legs, ankles or feet; increased blood pressure; discomfort from contact lenses; vision changes; yellowing of the skin or eyes, especially with fever, unusual tiredness, loss of appetite, dark urine, or light-colored bowel movements.

Other: Changes in menstruation, breast tenderness, nausea, vomiting, acne, hair loss, cramping, minor bloating, depression, anxiety, weight gain or loss, headache, sensitivity to the sun; darkening of skin on the face.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • ACE inhibitors such as benazepril (Lotensin), captopril, enalapril (Vasotec), fosinopril, lisinopril (Prinivil, Zestril), quinapril (Accupril), and ramipril (Altace)
  • alcohol
  • aminoglutethimide (Cytadren)
  • angiotensin receptor II blockers such as candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), losartan (Cozaar), olmesartan (Benicar), telmisartan (Micardis), and valsartan (Diovan)
  • antibiotics such as ciprofloxacin (Cipro), clarithromycin (Biaxin), and erythromycin (Ery-Tab, E.E.S.)
  • antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral)
  • antiseizure medicines such as carbamazepine (Tegretol), ethotoin (Peganone), fosphenytoin (Cerebyx), gabapentin (Neurontin), lamotrigine (Lamictal), levetiracetam (Keppra), oxcarbazepine (Trileptal), phenobarbital, phenytoin (Dilantin), primidone (Mysoline), tiagabine (Gabitril), topiramate (Topamax), and valproic acid (Depakene, Depakote)
  • medicine that reduces the chance of blood clots forming such as heparin and warfarin (Coumadin)
  • calcium channel blockers such as diltiazem (Cardizem, Tiazac) and verapamil (Isoptin, Calan)
  • cholesterol-lowering medicines (statins) such as atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor)
  • cimetidine (Tagamet)
  • corticosteroids such as betamethasone (Celestone), cortisone, dexamethasone, fludrocortisone (Florinef), hydrocortisone (Cortef), methylprednisolone (Medrol), prednisolone (Orapred), prednisone, and triamcinolone (Aristospan, Kenalog)
  • cyclosporine (Neoral, Sandimmune, Gengraf)
  • dantrolene (Dantrium)
  • diabetes medicines such as glipizide (Glucotrol), glyburide (DiaBeta), insulin, metformin (Glucophage), pioglitazone (Actos), repaglinide (Prandin), and rosiglitazone (Avandia)
  • diuretics such as amiloride, spironolactone (Aldactone), and triamterene (Dyrenium)
  • eplerenone (Inspra)
  • lithium (Lithobid)
  • medicines to treat HIV such as indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), and ritonavir (Norvir, Kaletra)
  • natural remedies such as alfalfa, black cohosh, bloodroot, chasteberry, dong quai, evening primrose oil, ginseng, red clover, saw palmetto, St. John's wort, soy, topical progesterone, and wild yam
  • nonsteroidal anti-inflammatory medicines (NSAIDs) such as diclofenac (Voltaren, Cataflam), ibuprofen (Motrin, Motrin IB, Advil), indomethacin (Indocin), ketoprofen, ketorolac (Toradol), nabumetone (Relafen), naproxen (Naprosyn, Anaprox, Aleve, Naprelan), oxaprozin (Daypro), piroxicam (Feldene), and sulindac (Clinoril)
  • potassium supplements such as K-Dur, Kaochlor, Kaon, Kaon-Cl, Kay Ciel, Klor-Con, Klorvess, K-Lyte, K-Lor, and Micro-K, and Slow-K
  • rifampin (Rifadin, Rimactane)
  • salt substitutes containing potassium
  • aminophylline and theophylline
  • thyroid medicine such as levothyroxine (Levothroid, Levoxyl, Synthroid, Unithroid), liothyronine (Cytomel, Triostat), liotrix (Thyrolar), and thyroid (Armour Thyroid, Thyroid Extract, Thyroid USP)
  • tricyclic antidepressants such as amitriptyline, desipramine (Norpramin), doxepin, imipramine (Tofranil), and nortriptyline (Pamelor)

Do not eat grapefruit or drink grapefruit juice while taking this medicine. Grapefruit affects the way this medicine works and may increase the risk of side effects.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-11-29
Last reviewed: 2010-12-22
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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