Erythromycin, Oral/Injection er-ith-roh-MY-sin

What are other names for this medicine?

Type of medicine: antibiotic

Generic and brand names: erythromycin base, oral; erythromycin stearate, oral; erythromycins, oral; erythromycin lactobionate, injection; E.E.S.; E-Mycin; Ery-Tab; EryPed; Erythrocin Stearate; Erythromycin Base Filmtabs; PCE Dispertab; Pediamycin

What is this medicine used for?

This medicine is an antibiotic taken by mouth or given by injection to treat bacterial infections.

It may be used for other conditions as determined by your healthcare provider.

This medicine will not cure viral infections such as colds and the flu.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• an allergic reaction to any medicine
• an irregular heart rhythm
• liver problems
• myasthenia gravis

Do not take this medicine if you are taking pimozide (Orap) or some medicines used for migraines such as Cafergot.

Females of childbearing age: Tell your healthcare provider if you are pregnant or if you plan to become pregnant. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes. Do not take more or less or take it longer than prescribed. Do not stop taking this medicine without your healthcare provider's approval, even if you feel better. If you stop taking it too soon, the infection may return.

This medicine comes in capsule, tablets, liquid and injection forms.

Taking this medicine with meals may lessen the chance the drug will upset your stomach. Follow your healthcare provider's directions.

Enteric-coated, extended-release, and delayed-release tablets and capsules must be swallowed whole. Ask your healthcare provider or pharmacist which type of tablets you have.

If you have the liquid form, shake the bottle well before pouring a dose. Measure the liquid with a marked measuring spoon or medicine cup. The average household teaspoon may not hold the right amount of liquid.

The injections are given by IV infusion (slow drip through a needle into a large vein) by your healthcare provider, usually when you are in a hospital. Your healthcare provider may switch you to tablets, or oral liquid when you leave the hospital.

What if I miss a dose?

Do not miss any doses. If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: nausea, vomiting, diarrhea, stomach pain.

What should I watch out for?

Do not take this medicine for other infections unless your healthcare provider approves. Do not use it beyond the expiration date on the label.

Contact your healthcare provider if your condition does not improve in a few days or if it gets worse.

If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you are taking this medicine.

If you take this medicine for a long time, you may need to have lab tests regularly to see how this medicine affects you. Keep all appointments for these tests.

This medicine may cause diarrhea. Severe watery and bloody diarrhea may be a sign of a life-threatening condition. If you develop severe diarrhea while taking this medicine or even as late as two or more months after having taken the last dose of this medicine, contact your healthcare provider right away. Do not take medicine to treat diarrhea without your provider's approval.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Severe stomach pain, dark urine, unusual bruising or bleeding, light-colored bowel movements, hearing problems, weakness, yellowish eyes or skin, irregular heartbeat.

Other: Diarrhea, nausea, vomiting, stomach cramps or upset, headache, pain or redness at injection site.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• any other antibiotics such as ciprofloxacin (Cipro), erythromycin (Ery-Tabs, E.E.S.), rifabutin (Mycobutin), and rifampin (Rifadin)
• antidepressants such as amitriptyline, amoxapine, desipramine (Norpramin), doxepin, fluoxetine (Prozac, Sarafem), imipramine (Tofranil), nefazodone, protriptyline (Vivactil) and sertraline (Zoloft)
• antifungal medicines such as fluconazole (Diflucan), itraconazole (Sporanox), and voriconazole (Vfend)
• antinausea medicines such as aprepitant (Emend), dolasetron (Anzemet), droperidol (Inapsine), and prochlorperazine
• antipsychotic medicines such as chlorpromazine, clozapine (Clozaril), haloperidol (Haldol), pimozide (Orap), quetiapine (Seroquel), risperidone (Risperdal), thioridazine, and ziprasidone (Geodon)
• antiseizure medicines such as carbamazepine (Tegretol), phenytoin (Dilantin), and valproic acid (Depakote, Depakene)
• benzodiazepines such as alprazolam (Xanax), diazepam (Valium), midazolam (Versed), and triazolam (Halcion)
• birth control pills
• bromocriptine (Parlodel)
• buspirone (BuSpar)
• calcium channel blockers such as diltiazem (Cardizem), nicardipine (Cardene), nifedipine (Procardia, Adalat), and verapamil (Calan)
• chemotherapy medicines such as vinblastine and vincristine
• cholesterol-lowering medicines (statins) such as atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor)
• cilostazol (Pletal)
• colchicine
• digoxin (Lanoxin)
• eplerenone (Inspra)
• ergot medicines such as dihydroergotamine (D.H.E. 45), ergotamine (Ergomar), and methysergide (Sansert)
• erlotinib (Tarceva)
• imatinib (Gleevec)
• immunosuppressants such as cyclosporine (Sandimmune, Neoral), sirolimus (Rapamune), and tacrolimus (Prograf, Protopic)
• medicine for irregular heart rhythms such as amiodarone (Cordarone), disopyramide (Norpace), dofetilide (Tikosyn), dronedarone (Multaq), flecainide (Tambocor), quinidine, and sotalol (Betapace)
• medicines to treat erectile dysfunction such as sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra)
• medicines to treat HIV such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), saquinavir (Invirase), and zidovudine (Retrovir, AZT)
• methylprednisolone (Medrol)
• St. John's wort
• theophylline
• venlafaxine (Effexor)
• warfarin (Coumadin)
• zafirlukast (Accolate)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store the liquid form of this medicine in the refrigerator. Do not let it freeze. Store tablets and capsules at room temperature. Protect the medicine from heat, high humidity, and bright light. Discard any unused liquid after 14 days because it loses its strength. If you have the EES oral suspension, discard any unused medicine after 10 days.

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.