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Erythromycin/Sulfisoxazole, Oral eh-rith-roh-MY-sin sul-fi-SOKS-a-zole

What are other names for this medicine?

Type of medicine: antibiotic

Generic and brand names: erythromycin and sulfisoxazole, oral; E.S.P.

What is this medicine used for?

This medicine is a combination of 2 antibiotics taken by mouth. It is used to treat ear infections and other infections caused by bacteria. This medicine will not cure viral infections such as colds and the flu.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • a blood disorder such as G6PD or anemia
  • asthma
  • heart rhythm problems
  • liver or kidney disease
  • myasthenia gravis
  • porphyria (nerve pain or sensitivity to sunlight)

Do not take this medicine if you are taking pimozide (Orap).

Females of childbearing age: Talk with your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval. This medicine should not be used by pregnant women at term, children less than 2 months of age, or by mothers nursing infants less than 2 months of age.

How do I take it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes, in regularly spaced doses day and night. Do not stop taking this medicine without your healthcare provider's approval. Take this medicine for as long as your healthcare provider tells you, even if you feel better. If you stop too soon, the infection may return.

This medicine comes in a liquid form. Shake the bottle well before measuring a dose. Use a specially marked dosing spoon or cup to measure the correct dose.

You can take this medicine with or without meals. Take it with a full glass of water.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: loss of appetite, nausea, vomiting, diarrhea, headache, dizziness, stomach pain, drowsiness, fever.

What should I watch out for?

Contact your healthcare provider if your condition does not improve or if it gets worse.

This medicine may make your skin more sensitive to the sun and may cause you to sunburn more easily. While you are taking this medicine, avoid long exposure to the sun. While you are in the sun, wear protective clothing and sunscreen lotion until you know how you will react to the sun. Do not use a sunlamp. If you get a severe sunburn, contact your healthcare provider right away.

This medicine may make you dizzy. Do not drive or operate machinery unless you are fully alert.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Severe stomach pain, dark urine, light-colored bowel movements, hearing problems, severe weakness, yellowish eyes or skin, irregular heartbeat, muscle pain, sore throat, fever, severe diarrhea, unusual bleeding or bruising, extreme tiredness, decreased urination.

Other: Sensitivity to sun, diarrhea, loss of appetite, mild dizziness, nausea, vomiting.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • antianxiety medicines such as alprazolam (Xanax), clonazepam (Klonopin), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), and oxazepam
  • antiarrhythmics such as amiodarone (Cordarone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), flecainide (Tambocor), procainamide, quinidine, and sotalol (Betapace)
  • antibiotics such as moxifloxacin (Avelox)
  • antidepressants such as fluoxetine (Prozac, Sarafem), nefazodone, paroxetine (Paxil), and sertraline (Zoloft)
  • antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), and voriconazole (V-fend)
  • antiseizure medicine such as carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), and primidone (Mysoline)
  • asthma medicines such as zafirlukast (Accolate) and zileuton (Zyflo)
  • bromocriptine (Parlodel)
  • buspirone (BuSpar)
  • calcium channel blockers such as diltiazem (Cardizem, felodipine, isradipine (DynaCirc CR), nicardipine (Cardene), nifedipine (Adalat CC, Procardia), and verapamil (Calan, Covera-HS, Isoptin SR, Verelan, Tiazac)
  • cholesterol-lowering medicines such as atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor)
  • clozapine (Clozaril)
  • colchicine
  • diabetes medicines such as glipizide (Glucotrol, Glucotrol XL), glyburide (DiaBeta, Glynase PresTab), insulin, metformin (Glucophage), pioglitazone (Actos), repaglinide (Prandin), and rosiglitazone (Avandia)
  • digoxin (Lanoxin)
  • eplerenone (Inspra)
  • ergot medicines (Ergomar, Cafergot, Migergot, D.H.E. 45, Migranal)
  • immunosuppressants such as azathioprine (Imuran), cyclosporine (Gengraf, Sandimmune, Neoral), mycophenolate mofetil (CellCept), sirolimus (Rapamune), and tacrolimus (Prograf)
  • medicines to treat erectile dysfunction such as sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra)
  • methotrexate
  • methylprednisolone (Medrol)
  • pimozide (Orap)
  • theophylline
  • tolterodine (Detrol, Detrol LA)
  • warfarin (Coumadin)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine in the refrigerator. Do not let it freeze. Keep the container tightly closed. Protect it from heat, high humidity, and bright light. Discard the medicine after 14 days.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-07-15
Last reviewed: 2011-03-14
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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