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Folic Acid, Oral/Injection FOH-lik AS-id

What are other names for this medicine?

Type of medicine: vitamin; nutritional supplement

Generic and brand names: folic acid, injection; folic acid, oral; folate

What is this medicine used for?

This is a B complex vitamin that is needed for good health. It occurs naturally in certain foods. As a medicine it is used either alone or with other medicines to prevent or treat folic acid deficiency and certain types of low red blood cell counts (anemia).

It may be used for other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, your healthcare provider needs to find out what type of anemia you have. Taking folic acid without vitamin B-12 may make pernicious anemia worse. Before taking this medicine, tell your healthcare provider if you have ever had

  • an allergic reaction to any medicine
  • kidney problems
  • pernicious anemia

Females of childbearing age: Tell your healthcare provider if you are pregnant, plan to become pregnant, or are breast-feeding. This medicine is often given during pregnancy to reduce the risk of birth defects such as spina bifida and other conditions. It may also be recommended if you are breast-feeding.

How do I use it?

Injections are usually given by a healthcare provider.

Take the oral form of this medicine exactly as directed by your healthcare provider, or according to the directions on the package label. Do not stop taking this medicine without your healthcare provider's approval if you are being treated for folic acid deficiency.

Do not take large amounts (more than 0.4 mg per day) unless your healthcare provider approves. Follow your provider's instructions about diet and taking vitamin supplements.

What if I overdose?

Symptoms of an acute overdose have not been reported.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What should I watch out for?

Do not take folic acid for anemia unless you have been diagnosed by your healthcare provider. If you have pernicious anemia, taking folic acid without vitamin B-12 can cause serious problems such as:

  • depression
  • personality changes
  • tingling and numbness of hands and feet
  • unsteady walk
  • loss of sense of smell
  • loss of appetite

You may need blood tests while taking this medicine. Keep all appointments.

This medicine may make your urine a darker yellow than normal. It is not harmful.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you are unable to reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; tightness in your chest; swelling of your lips, tongue, or throat; trouble breathing).

Serious (report these to your healthcare provider right away): Fever, rash, itching, trouble breathing, depression, personality changes, confusion, tingling and numbness of hands and feet, unsteady walk, loss of sense of smell.

Other: Nausea, loss of appetite, tiredness, bitter taste in your mouth, trouble sleeping.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • antiseizure medicines such as phenobarbital, phenytoin (Dilantin), and primidone (Mysoline)
  • cholestyramine (Questran) and colestipol (Colestid) (take folic acid 1 hour before or 4 hours after these medicines)
  • methotrexate (Rheumatrex)
  • nitrofurantoin (Macrobid, Macrodantin)
  • pyrimethamine (Daraprim)
  • tetracycline

Do not drink alcohol while taking this medicine without your healthcare provider's approval.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-01-14
Last reviewed: 2011-01-14
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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