Type of medicine: nucleoside reverse transcriptase inhibitor; antiretroviral (anti-HIV)
Generic and brand names: lamivudine/zidovudine, oral; Combivir
This medicine is taken by mouth to treat HIV infection.
It is a combination of 2 medicines in one tablet.
It is usually taken with other medicines.
Before taking this medicine, tell your healthcare provider if you have ever had:
Tell your healthcare provider if you regularly drink alcohol or have a history of alcohol abuse.
Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant while taking this medicine. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine.
Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes. Do not take more of it or take it more often than directed. Do not stop taking this medicine or change your dosage unless directed to do so by your healthcare provider.
Do not let your medicine run out. The amount of virus in your blood may increase if you stop the medicine, even for a short time.
You may take this medicine with or without food.
If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.
If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.
Symptoms of an acute overdose may include: nausea, vomiting, loss of balance, headache, dizziness, drowsiness, confusion, seizures.
If you are also infected with hepatitis B, you need blood tests and checkups for several months after you stop taking this medicine. This medicine may cause flare-ups of hepatitis B.
This medicine may cause a severe or life-threatening condition called lactic acidosis (a buildup of acid in your blood). Contact your healthcare provider right away if you develop unexplained symptoms such as:
This medicine may cause severe or life-threatening liver problems. Contact your healthcare provider right away if you have:
You will need blood tests regularly to see how this medicine affects you. It is very important to keep these appointments. Talk with your healthcare provider about this.
This medicine may also cause muscle weakness, aches, and pain if taken for a long period of time. Talk with your healthcare provider about this.
This medicine may cause pancreatitis. Children may be more susceptible to this condition. When this medicine is given to children, parents should watch for symptoms such as sudden and severe stomach pain that may spread to the back or sides, severe nausea, vomiting, and fever.
Treatment with this medicine may cause a change in the location of fat in your body. Talk with your healthcare provider about this.
This medicine may make you dizzy or drowsy. Do not drive or operate machinery unless you are fully alert.
If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.
This medicine may cause immune reconstitution syndrome (IRS). As the immune system gets stronger, the body's responses to diseases such as Graves’ disease, polymyositis, and Guillain-Barré syndrome may also get stronger. Talk with your provider about this.
This medicine is not a cure for HIV infection. This medicine does not reduce the risk of infecting other people through sexual contact or blood contamination. There is no information about the effects of long-term treatments.
Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.
Life-threatening (Report these to your healthcare provider right away. If you are unable to reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives, itching, rash, tightness in your chest, swelling of your lips, tongue or throat, trouble breathing).
Serious (report these to your healthcare provider right away): Slow, fast, or irregular heartbeat; chest pain; dark urine; severe diarrhea; fever; light-colored bowel movements; unusual loss of appetite; unusual muscle or joint pain; feeling cold; severe nausea or tiredness; pale skin; severe muscle weakness; shortness of breath; severe stomach pain; seizures; severe dizziness; severe back or leg pain; tingling, numbness, or pain in the hands or feet; unexplained cough or sore throat; unusual bruising or bleeding; sores that don't heal; persistent vomiting; yellow skin or eyes; increasing drowsiness; any skin redness, peeling, or blisters.
Other: Headache, nausea, tiredness, diarrhea, loss of appetite, dizziness, trouble sleeping, depression, runny nose, sore throat, cough, changes in body fat, hair loss.
When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:
Do not drink alcohol while you are taking this medicine. Talk with your healthcare provider about this.
If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.
Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.
This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.
Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.
Keep all medicines out of the reach of children.
Do not share medicines with other people.
