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Orphenadrine, Oral/Injection or-FEN-a-dreen

What are other names for this medicine?

Type of medicine: skeletal muscle relaxant

Generic and brand names: orphenadrine, oral; orphenadrine, injection; Norflex

What is this medicine used for?

This medicine is used to relax your muscles to relieve pain from sprains, spasms, or injuries.

It may be used for other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • an enlarged prostate or trouble urinating
  • a sulfite allergy (injection form contains sodium bisulfite)
  • blockage of the stomach or intestines
  • glaucoma or high pressure in your eyes
  • heart disease or a fast or irregular heartbeat
  • kidney or liver problems
  • myasthenia gravis
  • problems with drug abuse
  • thyroid problems
  • trouble swallowing
  • ulcers

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Take this medicine exactly as your healthcare provider prescribes. Check the label on the medicine for directions about your specific dose. Do not take more or take it more often than directed. Your healthcare provider will adjust your dosage depending on how the medicine works for you. Do not stop taking this medicine without your healthcare provider's approval. Your dose may need to be gradually decreased to avoid side effects.

You may take this medicine with or without food. Taking it with meals may lessen the chance the drug will upset your stomach.

The shots will be given by your healthcare provider into a muscle or vein, usually when you are unable to take the medicine by mouth.

This medicine may come in different forms. If you have extended-release tablets or capsules, do not break, crush, or chew them. Swallow them whole. Ask your pharmacist if you have the extended-release form.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: blurred vision, cold clammy skin, coma, confusion, drowsiness, fast heartbeat, lightheadedness, seizures, shallow breathing.

What should I watch out for?

This medicine may make you feel dizzy or faint, especially when you get up from sitting or lying down. Getting up slowly may help. If you get dizzy or drowsy, do not drive or operate machinery until you are fully alert.

This medicine may cause dry mouth. Use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. If dry mouth lasts longer than 2 weeks, tell your healthcare provider about it.

Adults over the age of 65 may be at greater risk for side effects. Talk with your healthcare provider about this.

This medicine increases the effects of alcohol and other drugs that slow down your nervous system. Do not drink alcohol or take other medicines unless your healthcare provider approves.

Contact your healthcare provider if your condition does not improve or if it gets worse.

Your healthcare provider may want to see you regularly to see how this medicine affects you. Keep all appointments.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Decreased urination; eye pain; confusion; tremors; hallucinations; nervousness; fainting; fast or irregular heartbeat.

Other: Blurred vision, drowsiness, lightheadedness, dizziness, dry mouth, nausea, constipation, headache, pain or redness at the injection site.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • alcohol
  • antihistamines such as brompheniramine, chlorpheniramine (Chlor-Trimeton), clemastine (Tavist-1), dexchlorpheniramine (Polaramine), and diphenhydramine (Benadryl)
  • barbiturates such as butabarbital (Butisol), pentobarbital (Nembutal), and phenobarbital
  • natural remedies such as gotu kola, kava, St. John's wort, and valerian
  • other muscle relaxants such as baclofen (Gablofen, Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), dantrolene (Dantrium), methocarbamol (Robaxin), and tizanidine (Zanaflex)
  • pain medicines such as codeine, fentanyl (Duragesic, Actiq), hydrocodone/acetaminophen (Vicodin), hydromorphone (Dilaudid), meperidine (Demerol), morphine (Kadian, MS Contin), oxycodone (Roxicodone, OxyContin), oxycodone/acetaminophen (Percocet, Tylox), pentazocine (Talwin), and tramadol (Ultram)
  • phenothiazines such as chlorpromazine, fluphenazine, prochlorperazine, and thioridazine
  • sleeping pills such as amobarbital (Amytal), butabarbital (Butisol), flurazepam, temazepam (Restoril), triazolam (Halcion), zaleplon (Sonata), and zolpidem (Ambien)
  • tranquilizers such as alprazolam (Xanax), chlordiazepoxide (Librium), diazepam (Valium), and lorazepam (Ativan)
  • tricyclic antidepressants such as amitriptyline, doxepin, imipramine (Tofranil), and nortriptyline (Pamelor)

Do not drink alcohol while you are taking this medicine.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-04-18
Last reviewed: 2010-10-07
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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