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Promethazine/Codeine, Oral proh-METH-a-zeen KOH-deen

What are other names for this medicine?

Type of medicine: antihistamine; antitussive (cough suppressant)

Generic and brand names: promethazine with codeine, oral; Prometh with Codeine

What is this medicine used for?

This medicine is taken by mouth to relieve coughs due to allergies or the common cold. This medicine contains codeine, a narcotic and promethazine, an antihistamine.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • Addison's disease
  • breathing problems such as asthma, emphysema, or sleep apnea
  • a head injury or brain tumor
  • an enlarged prostate, bladder problems, or trouble urinating
  • glaucoma
  • heart disease
  • high or low blood pressure
  • stomach or intestinal blockage or ulcerative colitis
  • liver or kidney disease
  • problems with drug or alcohol abuse
  • seizures
  • thyroid problems

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval. Note that this medicine may cause false readings of some pregnancy tests.

How do I take it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes. Do not take more of it or take it longer than prescribed. Taking too much of this medicine can make you very drowsy and may be habit-forming.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: drowsiness, slow breathing, fast heartbeat, seizures, dry mouth, large pupils, flushing, dizziness, weakness, fainting, lightheadedness, nausea, stomach pain, coma.

What should I watch out for?

Do not give a child under age 6 any cough and cold medicines unless specifically instructed to do so by your healthcare provider. Talk with your healthcare provider about this.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

This medicine may cause drowsiness, dizziness, or blurred vision. Do not drive or operate machinery unless you are fully alert and can see clearly.

You may feel dizzy or faint when you get up quickly after sitting or lying down. Getting up slowly may help.

This medicine increases the effects of alcohol and other drugs that slow down your nervous system. Do not drink alcohol or take other medicines unless your healthcare provider approves.

This medicine may make your skin more sensitive to the sun and may cause you to sunburn more easily. While you are taking this medicine, avoid long exposure to the sun. While you are in the sun, wear protective clothing and sunscreen lotion until you know how you will react to the sun. Do not use a sunlamp. If you get a severe sunburn, contact your healthcare provider right away.

Adult over the age of 65 may be at greater risk for side effects. Talk with your healthcare provider about this.

This medicine may make you constipated. You may need to use a laxative or stool softener while taking this medicine. Talk with your healthcare provider or pharmacist about this.

This medicine is a controlled substance. It is illegal for you to give it to anyone else.

Diabetics: This medicine may affect your blood sugar level and change the amount of insulin or other diabetes medicines you may need. Talk with your healthcare provider about this.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you are unable to reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives, itching, rash, tightness in your chest, trouble breathing, swelling of your lips, tongue or throat).

Serious (report these to your healthcare provider right away): Involuntary tongue or facial movements, trouble breathing, muscle twitching, rapid or irregular heartbeat, fainting, trouble urinating, severe drowsiness, seizures.

Other: Drowsiness, dizziness, lightheadedness, dry mouth, nausea, vomiting, constipation, sensitivity to sunlight.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • antianxiety medicines such as alprazolam (Xanax), clonazepam (Klonopin), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), and oxazepam
  • anticholinergic medicines such as atropine sulfate, benztropine (Cogentin), dicyclomine (Bentyl), hyoscyamine (Levsin), methscopolamine (Pamine), propantheline, and trihexyphenidyl
  • antihistamines such as chlorpheniramine (Chlor-Trimeton), diphenhydramine (Benadryl), hydroxyzine (Vistaril), and meclizine (Antivert, Dramamine)
  • antinausea medicines such as prochlorperazine (Compro) and promethazine (Phenergan)
  • antipsychotic medicines such as chlorpromazine, clozapine (Clozaril), fluphenazine, haloperidol (Haldol), olanzapine (Zyprexa), perphenazine, trifluoperazine, and thioridazine
  • antiseizure medicines such as carbamazepine (Tegretol), felbamate (Felbatol), gabapentin (Neurontin), lamotrigine (Lamictal), levetiracetam (Keppra), phenytoin (Dilantin), primidone (Mysoline), tiagabine (Gabitril), and topiramate (Topamax)
  • diabetes medicines such as glipizide (Glucotrol, Glucotrol XL), glyburide (DiaBeta, Glynase PresTab), insulin, metformin (Glucophage), pioglitazone (Actos), repaglinide (Prandin), and rosiglitazone (Avandia)
  • natural remedies such as gotu kola, kava, St. John's wort, and valerian
  • MAO inhibitor antidepressants such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam), and tranylcypromine (Parnate) (Do not take this medicine and an MAO inhibitor within 14 days of each other.)
  • muscle relaxants such as baclofen (Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), methocarbamol (Robaxin), and tizanidine (Zanaflex)
  • narcotic pain medicines such as codeine, fentanyl (Duragesic, Actiq), hydrocodone/acetaminophen (Vicodin), hydromorphone (Dilaudid), meperidine (Demerol), morphine (Kadian, MS Contin), oxycodone (OxyContin, Roxicodone), oxycodone/acetaminophen (Percocet, Tylox), and pentazocine (Talwin)
  • sleeping pills such as butabarbital (Butisol), flurazepam, phenobarbital, temazepam (Restoril), triazolam (Halcion), zaleplon (Sonata), and zolpidem (Ambien)
  • SSRI antidepressants such as fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox CR), paroxetine (Paxil), and sertraline (Zoloft)
  • tricyclic antidepressants such as amitriptyline, desipramine (Norpramin), doxepin, imipramine (Tofranil), and nortriptyline (Pamelor)

Do not drink alcohol while taking this medicine.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-07-15
Last reviewed: 2010-05-12
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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