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Sulfamethoxazole/Trimethoprim, Oral/Injection sul-fa-meth-OKS-a-zole try-METH-oh-prim

What are other names for this medicine?

Type of medicine: sulfonamide (anti-infective)

Generic and brand names: sulfamethoxazole/trimethoprim, injection; sulfamethoxazole/trimethoprim, oral; cotrimoxazole, oral; Bactrim; Bactrim DS; Septra; Septra DS; Sulfamethoxazole-Trimethoprim Suspension; Sulfamethoxazole-Trimethoprim DS

What is this medicine used for?

This medicine is taken by mouth to treat or prevent bacterial infections. It will not cure viral infections such as colds or the flu.

What should my healthcare provider know before I take this medicine?

Before you take this medicine, tell your healthcare provider if you have:

  • an allergy to any medicines
  • asthma or severe allergies
  • a blood disorder such as anemia or G6PD
  • diabetes
  • kidney or liver disease
  • porphyria (nerve pain or sensitivity to sunlight)
  • thyroid problems

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. This medicine is not usually given to women in their last 3 months of pregnancy because it can harm the baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I use it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes for the length of time prescribed, even if you feel better. It is best to take doses at evenly spaced times day and night to keep a steady amount in your body.

Take this medicine with a full glass (8Â ounces) of water. Your healthcare provider may want you to drink more liquids while you are taking this medicine to help prevent some of its side effects.

This medicine comes in several forms. If you have the liquid form of this medicine, shake it well before taking the medicine. Use a specially marked measuring spoon to measure each dose. The average household teaspoon may not hold the right amount of liquid.

This medicine may also be given by injection (shots) by your healthcare provider if your infection is severe or complicated.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: nausea, vomiting, diarrhea, loss of appetite, dizziness, confusion, drowsiness, headache, decreased urination, stomach pain, bloody urine.

What should I watch out for?

This medicine may cause diarrhea. Severe watery and bloody diarrhea may be a sign of a life-threatening condition called pseudomembranous colitis. If you develop diarrhea while taking this medicine, or up to 2 or more months after the last dose of this medicine, contact your healthcare provider. Do not take medicine to treat diarrhea without your provider's approval. Do not take this medicine for other infections or give it to an infant less than 2 months of age unless your healthcare provider approves.

You may need to have blood tests to see how this medicine affects you. Keep all appointments.

This medicine may make your skin more sensitive to the sun and may cause you to sunburn more easily. While you are taking this medicine, avoid long exposure to the sun. While you are in the sun, wear protective clothing and sunscreen lotion until you know how you will react to the sun. Do not use sunscreen that contains PABA. Do not use a sunlamp. If you get a severe sunburn, contact your healthcare provider right away. This reaction may occur even after you stop taking the medicine.

Adults over the age of 65 may be at greater risk for side effects. Talk with your healthcare provider about this. If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; tightness in your chest; swelling of your lips, tongue, or throat; trouble breathing).

Serious (Report these to your healthcare provider right away): Bloody urine; difficult or painful urinating; weakness; sore throat; fever; severe headache; paleness; yellowing of your eyes and skin; muscle or joint pain; reddish or purplish skin spots or peeling of the skin; unusual tiredness or weakness; ringing in the ears; unusual bruising or bleeding; severe watery or bloody diarrhea.

Other: Headache, dizziness, mild diarrhea, mild nausea or vomiting, sensitivity to the sun.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • ACE inhibitors such as benazepril (Lotensin), captopril, enalapril (Vasotec), fosinopril, lisinopril (Prinivil, Zestril), quinapril (Accupril), and ramipril (Altace)
  • amantadine (Symmetrel)
  • aminobenzoate potassium (Potaba)
  • antiseizure medicines such as carbamazepine (Tegretol), phenobarbital, and phenytoin (Dilantin)
  • cyclosporine (Sandimmune, Gengraf, Neoral)
  • dapsone
  • digoxin (Lanoxin)
  • heart medicines such as dofetilide (Tikosyn) and procainamide
  • indomethacin
  • medicines for diabetes such as chlorpropamide, glimepiride (Amaryl), glipizide (Glucotrol), glyburide (DiaBeta, Glynase), tolazamide, and tolbutamide
  • methenamine (Hiprex)
  • methotrexate
  • natural remedies such as dong quai and St. John's wort
  • probenecid
  • pyrimethamine (Daraprim)
  • sunscreens containing PABA
  • thiazide diuretics such as chlorthalidone (Thalitone), chlorothiazide (Diuril), hydrochlorothiazide (Microzide), and methyclothiazide
  • tricyclic antidepressants such as amitriptyline, desipramine (Norpramin), doxepin, imipramine (Tofranil), and nortriptyline (Pamelor)
  • warfarin (Coumadin)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-08-08
Last reviewed: 2011-05-17
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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