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Acetazolamide, Oral a-set-a-ZOH-la-mide

What are other names for this medicine?

Type of medicine: carbonic anhydrase inhibitor

Generic and brand names: acetazolamide, oral; Diamox; Diamox Sequels

What is this medicine used for?

This medicine is taken by mouth to treat:

  • altitude sickness
  • certain kinds of seizures
  • edema (swelling)
  • glaucoma

It may be used for other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • adrenal gland problems such as Addison's disease
  • diabetes
  • liver or kidney disease
  • low levels of sodium or potassium in the blood
  • lung disease

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes. Taking more may increase the risk of side effects.

Take this medicine with meals to lessen stomach upset. If stomach upset continues, tell your healthcare provider.

This medicine may increase urination. Take the last dose of the day before 6 PM to avoid interrupting your sleep.

If you are taking this medicine to control seizures, do not stop taking it without your healthcare provider's approval.

This medicine may come in different forms. If you have the extended-release capsules, do not break, crush, or chew them. Swallow them whole. Ask your pharmacist if you have the extended-release capsules.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: tremors, sweating, fast heartbeat, seizures, severe confusion, coma, drowsiness, decreased appetite, nausea, vomiting, dizziness, numbness, tingling.

What should I watch out for?

Your healthcare provider may want to see you regularly to check your progress. You will also need regular eye exams while taking this medicine.

If you develop hives, an itchy rash, or peeling skin, stop taking the medicine and contact your provider right away.

This medicine may change the levels of potassium and fluid in your body. Talk with your provider about your diet and about how much liquid you should drink.

This medicine may make you drowsy or dizzy. Do not drive or operate machinery unless you are fully alert.

This medicine may make your skin more sensitive to the sun, which may lead to painful sunburns. While you are taking this medicine, avoid long exposure to the sun. Wear protective clothing, a hat, and sunscreen lotion when you need to be outdoors. Do not use a sunlamp.

Adults over the age of 65 may be at greater risk for side effects. Talk with your provider about this.

If you need lab tests, emergency care, surgery, or dental work, tell all healthcare providers and dentists that you are taking this medicine.

Diabetics: This medicine may affect your blood sugar level and change the amount of insulin or other diabetes medicines you may need. Talk to your healthcare provider about this.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Severe skin rash, redness, blisters or peeling; extreme weakness; trouble urinating; depression; yellowing of the skin or eyes; bloody or black tarry stools; blood in the urine; unusual bleeding or bruising; seizures; dark urine; severe stomach pain; light colored stools; confusion; tingling in the hands or feet.

Other: Diarrhea, nausea, vomiting, increased urination, loss of appetite, change in sense of taste, ringing in the ears, drowsiness.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Also, using these medicines together might cause harmful side effects. Talk to your healthcare provider if you are taking any of these medicines:

  • alcohol
  • amitriptyline
  • amphetamines such as amphetamine sulfate, dextroamphetamine (Dexedrine), and methamphetamine (Desoxyn)
  • aspirin in high doses and salicylates such as aminosalicylic acid (Paser), choline magnesium trisalicylate, salsalate
  • cyclosporine (Sandimmune, Neoral, Gengraf)
  • lithium (Lithobid, Eskalith)
  • medicines to treat diabetes such as glimepiride (Amaryl), glipizide (Glucotrol, Glucotrol XL), and glyburide (DiaBeta)
  • diflunisal
  • primidone (Mysoline)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-05-10
Last reviewed: 2011-05-09
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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