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Bivalirudin, Injection by-val-ih-ROO-din

What are other names for this medicine?

Type of medicine: anticoagulant (medicine that reduces the chance of blood clots forming); thrombin inhibitor

Generic and brand names: bivalirudin, injection; Angiomax

What is this medicine used for?

This medicine reduces the chance of blood clots forming for people with unstable angina (chest pain). The medicine is given by injection to prevent or dissolve blood clots during angioplasty. Angioplasty is a procedure used to unblock a blood vessel.

This medicine may be used for other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • bleeding problems
  • high blood pressure
  • a stroke
  • kidney problems
  • ulcers

Tell your healthcare provider if you have recently had surgery or major bleeding problems.

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I use it?

You will receive a shot in your IV tubing, then a 4 hour IV infusion (slow drip). After the first 4 hour infusion you may receive another treatment. You may also be given aspirin to take by mouth.

What should I watch out for?

There is a risk of bleeding at the spot where you have your IV.

Use a soft brush to brush your teeth. Be careful while shaving, cutting fingernails or toenails, or when using sharp objects. Avoid sports and activities that may cause injuries. If you fall or are injured, contact your healthcare provider right away.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you have received this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away). If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; chest pain or tightness in your chest; swelling of your lips, tongue, and throat).

Serious (contact your healthcare provider right away): Heavy bleeding or pain at the IV site, nose bleeds, bleeding gums, black tarry stool, blood in urine, chest pain, severe dizziness, fainting, slow heartbeat, severe headache, vision changes, fever, trouble urinating.

Other: Back pain, headache, nausea, lightheadedness, stomach pain, trouble sleeping, anxiety, nervousness, stomach upset, vomiting.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • aspirin or other salicylates
  • medicines to treat or prevent blood clots such as abciximab (ReoPro), argatroban, clopidogrel (Plavix), dipyridamole (Persantine), eptifibatide (Integrilin), lepirudin (Refludan), tirofiban (Aggrastat), and warfarin (Coumadin)
  • natural remedies such as angelica, arnica, capsicum, chamomile, fenugreek, garlic, ginger, ginkgo, Panax ginseng, horse chestnut, papain, passionflower, red clover, and willow
  • nonsteroidal anti-inflammatory medicines (NSAIDs) such as diclofenac (Voltaren, Cataflam), ibuprofen (Motrin, Motrin IB, Advil), indomethacin (Indocin), ketoprofen, ketorolac (Toradol), nabumetone (Relafen), naproxen (Naprosyn, Anaprox, Aleve, Naprelan), oxaprozin (Daypro), piroxicam (Feldene), and sulindac (Clinoril)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2010-07-28
Last reviewed: 2010-07-26
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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