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Clomiphene, Oral KLOH-mi-feen

What are other names for this medicine?

Type of medicine: infertility treatment

Generic and brand names: clomiphene, oral; Clomid; Milophene; Serophene

What is this medicine used for?

This medicine is taken by mouth to help women become pregnant. It is also used to treat other conditions in both men and women.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergy to any medicine
  • abnormal vaginal bleeding
  • blood clots or blood vessel disease
  • endometrial cancer
  • liver disease
  • ovarian cysts or uterine fibroids
  • thyroid, pituitary, or adrenal gland problems

Females of childbearing age: Do not take this medicine if you are pregnant. This medicine has been reported to cause birth defects. Stop taking this medicine at the first sign that you may be pregnant and contact your healthcare provider right away. Do not breast-feed while taking this medicine.

How do I take it?

Take this medicine exactly as directed, usually starting on the fifth day after your period starts.

What if I miss a dose?

Take the medicine at the same time each day to help you remember to take it. If you miss a dose, ask your healthcare provider what to do.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: nausea, vomiting, flushing, blurred vision, visual spots or flashes, stomach pain.

What should I watch out for?

Your healthcare provider will want to see you regularly to check your progress.

Your ovaries may become enlarged, which may cause mild abdominal bloating and pain. Contact your healthcare provider if these symptoms last more than 2 to 3 weeks or if they become severe.

Rarely, this medicine causes a condition called ovarian hyperstimulation syndrome. The symptoms are severe abdominal bloating and pain, nausea, vomiting, rapid weight gain, shortness of breath, and reduced urination. If you have these symptoms, or if you have burning when you urinate, contact your healthcare provider right away because you need special treatment.

This medicine may increase the chance of multiple births (two or more babies from one pregnancy). Talk with your healthcare provider about this.

This medicine may cause dizziness or vision problems. Do not drive or operate machinery unless you are fully alert and can see clearly.

Follow your healthcare provider's instructions for recording your body temperature and timing sexual intercourse to increase the likelihood of becoming pregnant.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Blurred vision or other vision problems; severe or sudden stomach or pelvic pain; unexplained swelling; shortness of breath; yellowish eyes or skin; severe nausea, vomiting, or diarrhea.

Other: Hot flashes, mood changes, breast pain or tenderness, dizziness, headache, heavy menstrual flow, cramps, nausea, vomiting, trouble sleeping.

What products might interact with this medicine?

No significant drug interactions have been reported for this medicine.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2012-01-31
Last reviewed: 2010-11-01
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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