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Colesevelam Hydrochloride, Oral koh-le-SEV-a-lam hy-droh-KLOR-ide

What are other names for this medicine?

Type of medicine: bile acid sequestrant; cholesterol-lowering

Generic and brand names: colesevelam hydrochloride, oral; WelChol

What is this medicine used for?

This medicine is taken by mouth to lower cholesterol levels when diet and exercise alone have not lowered them enough. It may be used alone or with other medicines.

This medicine is also used to help control blood sugar in adults with type 2 diabetes when taken with other antidiabetic medicines.

It may be used for other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have:

  • an allergy to any medicine
  • constipation, hemorrhoids, or bowel obstruction
  • type 1 diabetes
  • phenylketonuria (some forms of this medicine contain phenylalanine.)
  • problems swallowing
  • thyroid problems
  • ulcers
  • vitamin A, D, E, or K deficiency

Also tell your healthcare provider if you have had major abdominal surgery.

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes. Do not stop taking this medicine without your healthcare provider's approval. This medicine will work only when taken regularly.

This medicine comes in tablet and powder forms. Take this medicine with meals. If you have trouble swallowing the tablet, you may be able to take the powder form instead. Talk with your healthcare provider about this.

If you have the powder form of medicine, carefully follow the directions for mixing it with water. Do not take this medicine in its dry form. One powder packet should be mixed in 4 to 8 ounces of water. Stir well and drink.

Take other medicines at least 4 hours before taking this medicine. Talk with your provider about this.

Drink more liquid while you take this medicine to help prevent constipation. Talk to your healthcare provider about this.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: stomach pain, severe constipation, gas.

What should I watch out for?

This medicine may keep your body from absorbing certain vitamins and folic acid. Your healthcare provider may recommend that you take a vitamin supplement with folic acid.

This medicine is part of a complete program that includes diet and exercise. Follow the diet and exercise program your healthcare provider recommends.

You will need to have blood tests regularly to see how this medicine affects you. Keep all appointments for these tests.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (report these to your healthcare provider right away. If you are unable to reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reactions (hives, itching, rash, tightness in your chest, trouble breathing).

Serious (contact your healthcare provider right away): Trouble swallowing, severe stomach pain, severe nausea and vomiting, severe constipation.

Other: Constipation, upset stomach, muscle aches or pain, weakness, sore throat, headache, nausea, runny nose.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Also, using these medicines together might cause harmful side effects. Talk to your healthcare provider if you are taking any of these medicines:

  • cyclosporine (Gengraf, Neoral, Sandimmune)
  • medicines to treat diabetes such as glyburide (Micronase), pioglitazone (Actos) and rosiglitazone (Avandia)
  • phenytoin (Dilantin)
  • hormonal birth control pills or estrogen
  • thyroid hormones such as Thyroid USP, levothyroxine (Synthroid, Levothroid), liothyronine (Cytomel), and liotrix (Thyrolar)
  • vitamins A, D, E, and K
  • warfarin (Coumadin)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2010-10-25
Last reviewed: 2010-03-02
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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