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Dinoprostone Vaginal dy-noh-PROST-own

What are other names for this medicine?

Type of medicine: prostaglandin

Generic and brand names: dinoprostone, vaginal; Prostin E2; Cervidil

What is this medicine used for?

This medicine is given by vaginal suppository to end a pregnancy. It may also be used for other conditions as determined by your healthcare provider. Your healthcare provider will explain why you are receiving this medicine.

What should my healthcare provider know before I take this medicine?

Before using this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • anemia
  • asthma or other lung problems
  • diabetes
  • glaucoma
  • heart problems
  • high or low blood pressure
  • liver or kidney disease
  • pelvic inflammatory disease or surgery on your uterus
  • seizures

How do I use it?

This medicine is given at certain times until the pregnancy is ended and bleeding has stopped. These treatments usually take place in a hospital.

What should I watch out for?

Your healthcare provider will explain the use of this medicine and what to expect. Follow all your healthcare provider's instructions, both while in the hospital and after you go home from the hospital.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are using this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away). If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; chest pain or tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Nausea, vomiting, or diarrhea that is severe or continues; vaginal bleeding; chest pain; fast heartbeat; shortness of breath.

Other: Headache, hot flashes, shivering, dizziness, weakness, hiccups, cough, bad taste in mouth, dry mouth, blurred vision, backache, breast tenderness.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • ergot alkaloids such as methylergonovine (Methergine)
  • oxytocics (drugs used in labor and delivery)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-10-05
Last reviewed: 2011-01-14
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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