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Epinephrine, Aerosol ep-i-NEF-rin

Thumbnail image of: Metered-Dose Inhaler, How to Use with a Spacer: Illustration
Thumbnail image of: Metered-Dose Inhaler, How to Use: Illustration

What are other names for this medicine?

Type of medicine: bronchodilator

Generic and brand names: epinephrine, aerosol

What is this medicine used for?

This medicine is no longer available as of December 31, 2011. The manufacturer is developing a CFC-free formula, which must be then approved by the FDA.

This medicine has been available without a prescription. If you have this product, follow directions carefully. Ask your pharmacist or healthcare provider about anything you do not understand.

This medicine is known as a bronchodilator. Bronchodilators are commonly used to treat the symptoms of lung diseases such as emphysema, bronchitis, and asthma. They relieve difficulty in breathing, shortness of breath, coughing, and wheezing. They may be used 15 to 30 minutes before exercise to prevent exercise-induced asthma.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have:

  • an allergy to any medicine
  • diabetes
  • glaucoma
  • high blood pressure
  • heart disease including abnormal heartbeat and angina (chest pain)
  • mental illness or depression
  • trouble urinating or an enlarged prostate
  • seizures
  • thyroid problems

Talk with your healthcare provider if you are using any other short-acting aerosol bronchodilator or beta blocker medicine. When you use these medicines together with this one, it may affect your heart.

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I use it?

This medicine is inhaled by mouth from an aerosol inhaler.

Check the label on the medicine for directions about your specific dose. Use this medicine exactly as your healthcare provider prescribes. Do not change your dosage without your healthcare provider's approval. Do not stop taking this medicine without your healthcare provider's approval. Using too much may increase the risk of side effects. An adult should supervise the use of this medicine by a child.

Ask your healthcare provider if you should use this medicine during an asthma attack.

If you are using any other inhaled medicine, wait at least 5Â minutes between doses of your medicines.

Carefully read and follow all directions that come in your medicine package.

  1. Wash your hands before using this medicine.
  2. Take plastic mouthpiece off bottle.
  3. Place short end of mouthpiece on bottle.
  4. Turn bottle upside down. Place thumb on bottom of mouthpiece over circular button and forefinger on top of vial.
  5. Empty the lungs as completely as possible by exhaling.
  6. Place mouthpiece in mouth with lips closed around opening. Breathe in deeply while squeezing mouthpiece and bottle together. Release immediately and remove unit from mouth, then complete taking the deep breath, drawing the medicine into your lungs, holding breath as long as comfortable.
  7. Breathe out slowly keeping lips nearly closed. This helps distribute the medicine in the lungs.
  8. Place long end of mouthpiece back on bottle and cover with plastic cap.

Clean the mouthpiece after each use with hot, soapy water, rinse thoroughly, and dry with a clean, lint-free cloth. If you do not understand how to use the inhaler, ask your healthcare provider or pharmacist to demonstrate.

What if I miss a dose?

If you miss a dose, use it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and use the next one as directed. Do not use double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: chest pain, fast or irregular heartbeat, seizures, tremors, nervousness, muscle cramps or weakness.

What should I watch out for?

Check with your healthcare provider or pharmacist before using any nonprescription medicines, especially other inhaled medicines.

Avoid foods, drinks, or other products that contain caffeine while you are taking this medicine.

If you need to use the medicine more often, if your symptoms do not improve, or if your condition gets worse, contact your healthcare provider right away.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are using this medicine.

Diabetics: This medicine may affect your blood sugar level and change the amount of insulin or other diabetes medicines you may need. Talk to your healthcare provider about this.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Chest pain, increased trouble breathing, irregular or fast heartbeat, hallucinations (seeing or hearing things that are not there).

Other: Hoarseness, coughing, dry mouth, nausea, dizziness, headache, restlessness, trouble sleeping, trembling, pounding heartbeat, weakness.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • beta blockers such as acebutolol, atenolol (Tenormin), bisoprolol (Zebeta), carvedilol (Coreg), labetalol, metoprolol (Lopressor, Toprol XL), nebivolol (Bystolic), propranolol (Inderal), nadolol (Corgard), and sotalol (Betapace)
  • digoxin (Lanoxin)
  • diuretics such as bumetanide (Bumex), chlorothiazide (Diuril), furosemide (Lasix), hydrochlorothiazide (Microzide), and torsemide (Demadex)
  • entacapone (Comtan) or tolcapone (Tasmar)
  • ergot medicines for migraines such as Cafergot or Ergomar
  • phentolamine
  • MAO inhibitor antidepressants such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam), and tranylcypromine (Parnate) (Do not take this medicine and an MAO inhibitor within 14 days of each other.)
  • medicines that contain phenylephrine, pseudoephedrine, ephedrine, or caffeine (such as cough and cold medicines, pain medicines, stimulants, or weight loss medicines)
  • other bronchodilators
  • tricyclic antidepressants such as amitriptyline, doxepin, imipramine (Tofranil), maprotiline, and nortriptyline (Pamelor) (Do not take this medicine and a tricyclic antidepressant within 14 days of each other.)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Aerosol inhaler: Store at room temperature protected from heat. Do not puncture the canister. Do not use near heat or an open flame. Do not throw inhaler into an open fire or incinerator.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2012-01-04
Last reviewed: 2012-01-03
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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