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Etonogestrel Implant Contraception System ee-toh-nohr-JES-trel

What are other names for this medicine?

Type of medicine: contraceptive (birth control)

Generic and brand names: etonogestrel implant system; Implanon

What is this medicine used for?

This birth control device slowly releases medicine that will prevent pregnancy for up to 3 years.

What should my health care provider know before I take this medicine?

Before using this medicine, tell your health care provider if you have ever had:

  • an allergic reaction to any hormones or medicines
  • blood clots in your legs, lungs, brain, eyes, or head (stroke)
  • asthma
  • breast cancer, uterine cancer, or other hormone-related cancer
  • depression
  • diabetes
  • heart attack, or other heart disease
  • high blood pressure
  • high cholesterol or triglycerides
  • gallbladder or kidney disease
  • liver disease or liver tumor
  • migraines or headaches along with vomiting, double vision, unsteadiness, weakness, or personality changes
  • seizures
  • unexplained vaginal bleeding

Tell your healthcare provider if you smoke. Smoking while you are using this medicine increases the risk of serious side effects such as heart attack, stroke, and blood clots. The risk increases with age and the number of cigarettes smoked a day. Talk to your healthcare provider about ways to quit smoking.

Tell your healthcare provider if you have recently had a long period of bed rest after major surgery or a broken bone in a cast.

Females of childbearing age: Do not have the rod inserted in your arm if you know or suspect that you are pregnant. If you become pregnant contact your health care provider right away. If you are breast feeding and want to use this medicine, talk with your healthcare provider. It will not be inserted if you are breast feeding unless you delivered your baby more than 4 weeks ago.

How do I use it?

Your health care provider will place a flexible plastic rod the size of a matchstick under the skin of your upper arm. The rod slowly releases medicine into your bloodstream.

It is important to have this medicine inserted at the right time of your menstrual cycle. Use a backup method of birth control (such as condoms) for 7 days after the rod is put in. After this medicine is inserted, check that it is in place by gently pressing your fingertips over the skin in your arm where this medicine was inserted. You should be able to feel the small rod. This medicine must be removed at the end of 3 years. This medicine can be removed sooner if you want.

You must sign a Patient Consent Form before you receive this medicine. Make sure you understand what is on the form before you sign it. If you have any questions ask your healthcare provider. You will also receive a User Card to keep at home. The card will have information about the insertion and removal dates. Keep track of the removal date and keep all appointments.

What should I watch out for?

The most common side effect of this medicine is a change in your menstrual periods. Expect your period to be irregular while you are using this medicine. You may have more bleeding, less bleeding, or no bleeding. The time between periods may vary, and you may have spotting between periods. Talk with your healthcare provider about this.

After the rod is inserted, keep the incision clean and protected to avoid infection and keep the incision from opening. Keep the top bandage on for 24 hours and the small bandage dry, clean, and in place for 3 to 5 days. If the area becomes red and sore or the incision opens and the rod comes out, contact your health care provider right away.

This form of birth control does not protect against sexually transmitted diseases, AIDS, or HIV.

This medicine may increase your risk of ovarian cysts, strokes, blood clots, high blood pressure, heart attacks, gallbladder disease, and liver tumors. Talk with your healthcare provider about these risks.

The rod may be removed at any time for medical or personal reasons, but it must be removed after 3Â years. A new rod may then be implanted.

This medicine may increase your HDL cholesterol levels, decrease your LDL levels, and increase your blood triglyceride levels. Talk to your healthcare provider about this.

If you wear contact lenses and notice a change in your vision or it becomes difficult to wear your lenses, contact your healthcare provider.

If you are scheduled to have surgery or will be on bedrest, talk to your healthcare provider. You may need to stop taking hormones at least 4 to 6 weeks before the surgery and bedrest. If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are using this medicine. You may have a greater risk of blood clots.

Diabetics: This medicine may affect your blood sugar level and change the amount of insulin or other diabetes medicines you may need. Talk to your healthcare provider about this.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your health care provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away). If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; chest pain or tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your health care provider right away): Bleeding problems, irregular or heavy periods, spotting between periods, discharge from your breasts, sharp chest pain, sudden shortness of breath, calf pain, sudden severe headache or vomiting, sudden dizziness or fainting, sudden change in vision or loss of vision, trouble talking or seeing, weakness or numbness in one arm or leg, yellowish eyes or skin, dark urine, light colored bowel movements, severe abdominal pain, skin infection, depression, breast lumps.

Other: Headache, nervousness, nausea, dizziness, weight gain, acne, appetite changes, mood changes, muscle pain, breast pain, back pain, insertion site pain, sinus or chest infection, vaginal itching or discharge.

What products might interact with this medicine?

Some other medicines may make this medicine less effective at preventing pregnancy. Before using this medicine, talk with your healthcare provider if you are taking:

  • antifungals such as itraconazole (Sporanox), griseofulvin (Gris-Peg), and ketoconazole (Nizoral)
  • antiseizure medicines such as carbamazepine (Tegretol), ethotoin (Peganone), fosphenytoin (Cerebyx), gabapentin (Neurontin), lamotrigine (Lamictal), levetiracetam (Keppra), oxcarbazepine (Trileptal), phenytoin (Dilantin), primidone (Mysoline), tiagabine (Gabitril), topiramate (Topamax), and valproic acid (Depakene, Depakote),
  • barbiturates such as butabarbital (Butisol), pentobarbital (Nembutal), and phenobarbital
  • medicines to treat HIV such as delavirdine (Rescriptor), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), and saquinavir (Invirase)
  • modafinil (Provigil)
  • rifampin (Rifadin, Rimactane)
  • rifabutin (Mycobutin)
  • St. John's wort
  • warfarin (Coumadin)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-02-11
Last reviewed: 2010-12-22
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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