Type of medicine: tricyclic antidepressant
Generic and brand names: imipramine pamoate, oral; imipramine, oral; Tofranil; Tofranil-PM
This medicine is taken by mouth to relieve depression.
It is also used to treat bedwetting.
It may be used for other conditions as determined by your healthcare provider.
Before taking this medicine, tell your healthcare provider if you have ever had:
Also tell your provider if you have taken MAO inhibitors such as phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), or isocarboxazid (Marplan) within the past 2 weeks.
Females of childbearing age: This medicine is not usually given to pregnant women because it can harm the baby. If you are pregnant, tell your healthcare provider. Do not become pregnant during treatment with this medicine. If you become pregnant, contact your healthcare provider right away. Do not breast-feed while you are receiving this medicine.
Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes.
This medicine may take several weeks to work. Take this medicine exactly as your healthcare provider prescribes. Do not take more or less or take it longer than prescribed. Do not stop taking this medicine without your healthcare provider's approval. You may have to reduce your dosage gradually.
If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. If you take only one dose at bedtime and you miss the dose, do not take the medicine in the morning. Wait until the next night. Skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.
If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.
Symptoms of an acute overdose may include: fast or irregular heartbeat, extreme drowsiness, confusion, hallucinations, restlessness, vomiting, blurred vision, fever, sweating, muscle stiffness, lightheadedness, fainting, seizures, coma.
Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. Talk with your provider about this.
Behavior changes may be caused by the medicine or by depression or another mental illness. Contact your provider right away if you or your family notice any disturbing changes in your thoughts or behavior, such as:
If you need to take this medicine for more than a few days, do not stop taking it suddenly. You may have to reduce your dosage gradually to avoid withdrawal symptoms. Follow your healthcare provider's instructions.
This medicine may decrease sex drive or cause impotence in men (trouble having and keeping an erection).
This medicine may cause weight gain. Ask your healthcare provider about this.
You may need regular blood tests to find out how this medicine affects you. Keep all appointments for these tests.
This medicine may increase the effects of alcohol and other drugs that slow down your nervous system. Do not drink alcohol or take other medicines unless your healthcare provider approves.
This medicine may cause drowsiness or blurred vision. Do not drive or operate machinery unless you are fully alert and can see clearly.
This medicine may make you may feel dizzy if you get up quickly after sitting or lying down. Getting up slowly may help.
If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.
This medicine may make your skin more sensitive to the sun and may cause you to sunburn more easily. While you are taking this medicine, avoid long exposure to the sun. While you are in the sun, wear protective clothing and sunscreen lotion until you know how you will react to the sun. Do not use a sunlamp. If you get a severe sunburn, contact your healthcare provider right away.
This medicine may cause dry mouth. Sucking hard candy, taking sips of water, or chewing sugarless gum may help.
Adults over the age of 65 may be at greater risk for side effects. Talk with your healthcare provider about this.
Diabetics: This medicine may affect your blood sugar level and change the amount of insulin or other diabetes medicines you may need. Talk to your healthcare provider about this.
Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.
Life-threatening (Report these to your healthcare provider right away). If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; chest pain or tightness in your chest; swelling of your lips, tongue, and throat).
Serious (report these to your healthcare provider right away): Seizures; unusual weakness or tiredness; high fever with rash; inability to urinate; fast, slow, or irregular heartbeat; fever with increased sweating; severe muscle stiffness; twitching or involuntary movement of your body or face; fainting; yellowing of the skin or eyes; confusion; hallucinations; unexplained sore throat.
Other: Headache, dizziness, drowsiness, dry mouth, nausea, vomiting, bad taste, itching, weight gain or loss, constipation, diarrhea, stomach pain, blurred vision, abnormal production of milk in women, testicle swelling in men, breast enlargement, nightmares, change in sexual ability or desire.
When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:
The effects of this medicine may be increased if you take it with grapefruit juice. Talk with your healthcare provider about this.
If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.
Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.
This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.
Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.
Keep all medicines out of the reach of children.
Do not share medicines with other people.
