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Loxapine, Oral LOKS-a-peen

What are other names for this medicine?

Type of medicine: antipsychotic

Generic and brand names: loxapine succinate, oral

What is this medicine used for?

This medicine is taken by mouth to treat the symptoms of mental disorders such as schizophrenia.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • a brain tumor or head injury
  • asthma, emphysema, or other lung disease
  • breast cancer
  • enlarged prostate or trouble urinating
  • glaucoma
  • heart disease or an irregular heartbeat
  • kidney or liver disease
  • Parkinson's disease
  • problems with alcohol or drug abuse
  • seizures
  • trouble swallowing

Females of childbearing age: Talk with your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine. Taking this medicine during the last 3 months of pregnancy may cause problems for the baby. These symptoms may include agitation, tight muscles, floppy muscles, shaking, trouble breathing, or trouble feeding. Talk with your provider about this.

How do I take it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes. Do not take more or less or take it longer than prescribed. Do not stop taking this medicine without your healthcare provider's approval.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: drowsiness, slurred speech, restlessness, seizures, uncontrolled movement or stiffness in tongue, jaw, or neck, irregular heartbeat.

What should I watch out for?

Your healthcare provider may want to check you regularly to adjust the dosage.

Using this medicine for a long time may cause muscle spasms, twitching in the face and body, and uncontrolled tongue or jaw movement. Talk to your healthcare provider about this.

This medicine increases the effects of alcohol and other drugs that slow down your nervous system. Do not drink alcohol or take other medicines unless your healthcare provider approves.

This medicine may make your skin more sensitive to the sun, which may lead to painful sunburns. While you are taking this medicine, avoid long exposure to the sun. Wear protective clothing, a hat, and sunscreen lotion when you need to be outdoors. Do not use a sunlamp. If you get a severe sunburn, contact your healthcare provider right away.

This medicine may make you drowsy. Do not drive or operate machinery unless you are fully alert.

While taking this medicine, be careful when you exercise, especially when it is hot. This medicine affects your body's ability to cool down, and you may get too hot. If you get too hot, you might vomit, feel dizzy, have a fast heartbeat, get very stiff muscles, or be confused. Contact your provider right away if you have these symptoms.

Dry mouth is a common side effect of this medicine. If it becomes serious, contact your healthcare provider.

Older adults with dementia are at greater risk for side effects. Talk with your provider about this.

If you need emergency care, surgery, or dental work, tell your healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away). If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; chest pain or tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Tremors, muscle twitching or stiffness, vision problems, trouble breathing, weakness, extreme dizziness or drowsiness, trouble swallowing, seizures, fast or irregular heartbeat, unusual bleeding or bruising, yellowing of the skin or eyes, loss of balance, trouble walking.

Other: Dry mouth, mild drowsiness or dizziness, blurred vision, constipation, lightheadedness, nausea, vomiting, weight change, breast pain or swelling, trouble sleeping, menstrual changes, headache, rash.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • alcohol
  • antacids such as Mylanta, Maalox, Tums, Rolaids, or Amphojel (do not take within 2 hours of taking this medicine)
  • antibiotics such as moxifloxacin (Avelox)
  • antidepressants such as amitriptyline, doxepin, imipramine (Tofranil), nortriptyline (Pamelor), and trazodone
  • antihistamines such as brompheniramine (Dimetane), chlorpheniramine (Chlor-Trimeton), diphenhydramine (Benadryl), and promethazine (Phenergan)
  • antiseizure medicines such as carbamazepine (Tegretol), phenytoin (Dilantin), and primidone (Mysoline)
  • barbiturates such as butabarbital (Butisol), pentobarbital (Nembutal), and phenobarbital
  • lithium (Lithobid)
  • lorazepam (Ativan)
  • medicines to treat Parkinson's disease such as benztropine (Cogentin), bromocriptine (Parlodel), entacapone (Comtan), levodopa/carbidopa (Sinemet), pergolide (Permax), pramipexole (Mirapex), and ropinirole (Requip)
  • metoclopramide (Reglan)
  • muscle relaxants such as baclofen (Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), dantrolene (Dantrium), methocarbamol (Robaxin), and tizanidine (Zanaflex)
  • narcotic analgesics (painkillers) such as codeine, fentanyl (Duragesic, Actiq), hydrocodone (Vicodin, Lortab), hydromorphone (Dilaudid), meperidine (Demerol), methadone (Dolophine), morphine, oxycodone (OxyContin), oxycodone/acetaminophen (Percocet, Tylox), and pentazocine (Talwin)
  • natural remedies such as DHEA, gotu kola, kava, St. John's wort, and valerian
  • pyridostigmine (Mestinon)
  • sleeping pills such as alprazolam (Xanax), chlordiazepoxide (Librium), clonazepam (Klonopin), clorazepate (Tranxene), diazepam (Valium), flurazepam, lorazepam (Ativan), oxazepam, temazepam (Restoril), and triazolam (Halcion)
  • thioridazine
  • tramadol (Ultram)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-08-08
Last reviewed: 2011-02-28
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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