Octreotide Acetate, Depot Injection ok-TREE-oh-tide AS-eh-tate

What are other names for this medicine?

Type of medicine: growth hormone inhibitor; antidiarrheal

Generic and brand names: octreotide acetate, depot injection; Sandostatin LAR Depot

What is this medicine used for?

This medicine is given by injection (shots) to treat acromegaly. This condition occurs when the body produces too much growth hormone, causing the head, face, hands, or feet to grow too large.

This medicine may also be given to treat certain tumors that cause severe, watery diarrhea. It may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• an allergic reaction to any medicine
• diabetes
• gall bladder problems
• heart problems such as heart failure
• kidney or liver disease
• thyroid disease

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. You may be able to become pregnant while taking this medicine, even if you were unable to get pregnant before starting this medicine. Talk with your healthcare provider about birth control methods while taking this medicine. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I use it?

Sandostatin LAR depot (intramuscular) is a long-acting shot that is given once every 4 weeks. It is usually given by your healthcare provider.

What should I watch out for?

You may need regular lab tests to show how you are responding to the medicine and to check for side effects such as a decrease in thyroid function. Keep all appointments for these tests.

This medicine may affect the way your body absorbs dietary fat and vitamin B12. Talk with your healthcare provider about this.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are using this medicine.

Diabetics: This medicine may affect your blood sugar level and change the amount of insulin or other diabetes medicines you may need. Talk to your healthcare provider about this.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider): Severe diarrhea that continues, chest pain, irregular or slow heart beat, high blood pressure, swelling in arms or legs, blurred vision or eye pain, high or low blood sugar, severe stomach pain.

Other: Constipation, mild stomach discomfort, nausea, vomiting, bloating, headache, dizziness, tiredness, weakness, muscle or joint pain, back pain, pain at the spot of the injection, hair loss.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• antiarrhythmics (medicines to treat irregular heartbeat) such as amiodarone (Cordarone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), dronedarone (Multaq), flecainide (Tambocor), propafenone (Rythmol), procainamide, quinidine, and sotalol (Betapace)
• antibiotics such as ciprofloxacin (Cipro), clarithromycin (Biaxin), erythromycin (Erythrocin, E.E.S.), levofloxacin (Levaquin), moxifloxacin (Avelox), and pentamidine (NebuPent)
• antidepressants such as amitriptyline, doxepin, fluoxetine (Prozac), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), and sertraline (Zoloft)
• antipsychotic medicines such as chlorpromazine, haloperidol (Haldol), pimozide (Orap), quetiapine (Seroquel), risperidone (Risperdal), thioridazine, and ziprasidone (Geodon)
• arsenic trioxide (Trisenox)
• beta blockers such as atenolol (Tenormin), bisoprolol (Zebeta), carvedilol (Coreg), and metoprolol (Lopressor, Toprol)
• bromocriptine (Parlodel)
• calcium channel blockers such as diltiazem (Cardizem, Dilacor, Tiazac), felodipine, nifedipine (Procardia), and verapamil (Calan)
• cyclosporine (Sandimmune, Neoral, Gengraf)
• diuretics such as bumetanide, furosemide (Lasix), hydrochlorothiazide, and spironolactone (Aldactone)
• diabetes medicines such as acarbose (Precose), glipizide (Glucotrol), glyburide (DiaBeta, Glynase), insulin, metformin (Glucophage), pioglitazone (Actos), repaglinide (Prandin), and rosiglitazone (Avandia)
• methadone (Dolophine)
• natural remedies such as alfalfa, aloe, bilberry, burdock, celery, fenugreek, garcinia, garlic, ginger, ginseng, gymnema, and stinging nettle
• potassium, magnesium, or phosphate supplements such as K-Dur, Kaochlor, Kaon, Kaon-Cl, Kay Ciel, Klor-Con, Klorvess, K-Lyte, K-Lor, Micro-K, Slow-K, Mag-Ox, Slow-Mag, Neutra-Phos, and Neuta-Phos-K

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine in the refrigerator. Keep the container tightly closed. Protect it from heat, high humidity, and bright light. After dilution, use the suspension right away. Discard the unused medicine after 1 hour.

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicines in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.