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Paclitaxel, Protein-Bound, Injection PAK-lih-taks-el PROH-teen bownd

What are other names for this medicine?

Type of medicine: antineoplastic (anticancer)

Generic and brand names: paclitaxel, protein bound, injection; Abraxane

What is this medicine used for?

This medicine is given by IV infusion (slow drip through a needle into a large vein) to treat:

  • breast cancer

It may be used for other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • diabetes
  • heart problems
  • liver disease.
  • kidney disease
  • peripheral neuropathy (numbness, tingling, or burning in the hands or feet)

Tell your healthcare provider if you have recently had an infection or been exposed to chickenpox or shingles (herpes zoster).

Females of childbearing age: This medicine is not usually given to pregnant women because it can harm the baby. If you are pregnant, tell your healthcare provider. Do not become pregnant during treatment with this medicine. If you become pregnant, contact your healthcare provider right away. Do not breast-feed while you are receiving this medicine.

Men receiving this medicine should also use an effective birth control method during treatment with this medicine. Talk with your healthcare provider about this.

How do I use it?

Only healthcare providers experienced with this drug should prescribe it. It should only be given in a clinic or hospital where you can be monitored closely. These infusions are given by your healthcare provider.

What should I watch out for?

You need to have blood tests regularly to see how this medicine affects you. Keep all appointments for these tests.

You may get infections more easily. Contact your healthcare provider right away if you have any signs of infection such as fever, chills, or sore throat. Stay away from people with colds, flu, or other infections. Also, do not have any vaccines without getting your healthcare provider's approval first.

This medicine needs to be given on a regular schedule. Be sure to keep all your appointments for your treatment.

Tell your healthcare provider if you have any numbness, tingling, or burning in the hands and feet while receiving this medicine. Your healthcare provider may interrupt treatment and restart at a lower dose after symptoms improve.

This medicine may cause mouth sores. Use a soft bristle brush or mouth swab to brush your teeth.

You may need to drink more water while receiving this medicine. Talk with your healthcare provider about this.

This medicine may make you dizzy or drowsy. Do not drive or operate machinery unless you are fully alert.

Hair loss is common during this treatment. Your hair will grow back after the treatments are stopped.

This medicine is made from human blood. It is tested for viruses such as hepatitis and HIV. The risk of getting an infection from this medicine is very low, but it is still possible. Talk with your healthcare provider about this.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Severe tingling or burning in your hands or feet; black, tarry stools; blood in urine or stools; pinpoint red spots on skin; unusual bleeding or bruising; slow or irregular heartbeat; chest pain; fever; chills; cough; lower back or side pain; sore throat; painful mouth sores that keep you from drinking liquids; severe nausea or vomiting; severe diarrhea or stomach pain; yellow skin or eyes; trouble urinating; numbness, pain, or weakness in arms or legs; unexplained swelling; unusual tiredness or weakness; injection site pain, redness, or swelling.

Other: Hair loss, loss of appetite, muscle or joint pain, vision changes, diarrhea.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • antibiotics such as clarithromycin (Biaxin), erythromycin (Ery-Tabs, E.E.S.), isoniazid, norfloxacin (Noroxin), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane), and telithromycin (Ketek)
  • antidepressants such as fluoxetine (Prozac, Sarafem) and nefazodone
  • antifungals such as clotrimazole, fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral)
  • anti-HIV medicines such as delavirdine (Rescriptor), efavirenz (Sustiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), and saquinavir (Invirase)
  • antiseizure medicines such as carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), and primidone (Mysoline)
  • cimetidine (Tagamet)
  • gemfibrozil (Lopid)
  • heart medicines such as amiodarone (Cordarone, Pacerone), diltiazem (Cardizem, Dilacor, Tiamate, Tiazac), nicardipine (Cardene), quinidine, and verapamil (Calan, Covera, Isoptin)
  • live vaccines
  • natural remedies such as black cohosh, dong quai, gotu kola, kava, St. John's wort, and valerian
  • other cancer medicines such as carboplatin, cisplatin, or doxorubicin (Adriamycin)

The effects of this medicine may be increased if you take it with grapefruit juice. Talk with your healthcare provider about this.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-10-13
Last reviewed: 2010-11-01
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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