Type of medicine: antineoplastic (anticancer)
Generic and brand names: pazopanib, oral; Votrient
This medicine is taken by mouth to treat advanced kidney cancer.
Before taking this medicine, tell your healthcare provider if you have ever had:
Tell your healthcare provider if you have had surgery within the last 7 days or if you are scheduled to have surgery.
Females of childbearing age: This medicine is not usually given to pregnant women because it can harm the baby. If you are pregnant, tell your healthcare provider. Do not become pregnant during treatment with this medicine. If you become pregnant, contact your healthcare provider right away. Do not breast-feed while you are receiving this medicine.
Read the Medication Guide that comes in the medicine package when you start taking this medicine and each time you get a refill. Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes. Do not stop taking this medicine without your healthcare provider's approval. Treatment will be continued for as long as you continue to benefit and can tolerate the side effects.
Take this medicine on an empty stomach, at least 1 hour before or 2 hours after a meal. Do not crush or chew the tablets. Swallow them whole.
If you miss a dose, take it as soon as you remember unless it is less than 12 hours until the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.
If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.
Symptoms of an acute overdose may include: weakness, tiredness, stomach pain.
You need to have lab tests regularly to see how this medicine affects you. Keep all appointments for tests.
This medicine may also cause liver damage in some people. Contact your provider right away if you have symptoms of liver damage such as dark urine, yellowing of the skin and eyes, unexplained tiredness, pain in the upper right part of the stomach, loss of appetite, nausea, or vomiting.
If you need emergency care, surgery, lab tests, or dental work, tell the healthcare provider or dentist you are taking this medicine.
Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.
Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help.): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).
Serious (report these to your healthcare provider right away): Severe stomach pain or swelling; severe or worsening diarrhea; dark urine; yellowing of the skin and eyes; unusual bruising or bleeding; any signs of infection such as sore throat or fever; unusual tiredness or weakness; irregular or fast heartbeat; fainting; chest pain; pain in your arms, back, neck or jaw; shortness of breath; numbness or weakness on one side of your body; trouble talking or walking; severe headache or dizziness; black or tarry stools; vomiting blood; loss of appetite; redness, pain, or blisters on the palms of your hands or soles of your feet.
Other: Nausea, vomiting, diarrhea, gas, headache, tiredness, rash, change in sense of taste, loss of appetite, change in hair or skin color.
When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:
The effects of this medicine may be increased if you take it with grapefruit juice. Talk with your healthcare provider about this.
If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.
Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.
This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.
Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.
Keep all medicines out of the reach of children.
Do not share medicines with other people.
