Type of medicine: PEGylated uric acid specific enzyme
Generic and brand names: pegloticase, infusion; Krystexxa
This medicine is given by IV infusion to treat gout when other medicines have not worked well.
Before taking this medicine, tell your healthcare provider if you have ever had:
Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.
Read the Medication Guide when you start receiving this medicine and each time you get a infusion.
This medicine is given by IV infusion (slow drip through a needle into a large vein) by your healthcare provider.
You may be given a medicine to prevent allergic reactions before you receive this medicine. You will be monitored closely while receiving this medicine and after receiving this medicine.
This medicine may cause an serious, life-threatening, allergic reaction called anaphylaxis. It is only given where you can be monitored closely. This reaction may happen with any infusion and usually within 2 hours of an infusion. However, delayed reactions may also occur. Tell your healthcare provider immediately if you have a rash, hives, itching, dizziness, fast or slow heartbeat, trouble breathing, chest pain or chest tightness, trouble swallowing, or swelling of your lips, tongue, or throat.
This medicine may also cause an infusion reaction with symptoms such as rash or redness of the skin, chest discomfort, shortness of breath, itching, or feeling warm. Contact your healthcare provider immediately if you have any of these symptoms while receiving this medicine or after you have received this medicine.
This medicine may cause gout flares when you first start taking it. Talk with your provider about this.
You may need to have blood tests regularly to see how this medicine affects you. Keep all appointments.
Follow the diet program your healthcare provider recommends. Certain food or drinks may cause gout attacks. Talk with your healthcare provider about this.
If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.
Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.
Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat); trouble swallowing, chest pain, fast or slow heartbeat, dizziness or fainting.
Serious (report these to your healthcare provider right away): Rash or redness of the skin, feeling warm.
Other: Gout flares, nausea, vomiting, constipation, sore throat, bruising.
No significant drug interactions have been reported.
If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.
This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.
Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.
Keep all medicines out of the reach of children.
Do not share medicines with other people.
