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Pimozide, Oral PIH-moh-zide

What are other names for this medicine?

Type of medicine: antipsychotic

Generic and brand names: pimozide, oral; Orap

What is this medicine used for?

This medicine is taken by mouth to treat symptoms of Tourette's syndrome. It is used when uncontrolled body movements or vocal tics are severe and other medicines have not worked. It may be used for other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • a blockage in your intestines
  • an allergic reaction to any medicine
  • an enlarged prostate or trouble urinating
  • breast cancer
  • glaucoma
  • heart disease or an irregular heartbeat. You should not take this medicine if you have problems with an irregular heartbeat.
  • liver or kidney disease
  • long QT syndrome (problems with electrical activity in the heart muscle)
  • Parkinson’s Disease
  • problems with too much or too little magnesium or potassium in your blood
  • seizures

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval. Taking this medicine during the last 3 months of pregnancy may cause problems for the baby. Symptoms the baby may have include agitation, tight muscles, floppy muscles, shaking, trouble breathing, or trouble feeding. Talk with your provider about this.

How do I use it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes. Do not take more of it or take it more often than prescribed. Do not stop taking this medicine without your healthcare provider's approval. You may have to reduce your dosage gradually.

If this medicine is prescribed for a child, an adult should make sure it is taken properly.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: drowsiness, uncontrolled movement or stiffness in tongue, jaw, or neck, slowed breathing, irregular heartbeat, dizziness, lightheadedness, fainting.

What should I watch out for?

Older adults with dementia are at greater risk for side effects. Talk with your provider about this.

You may need to have an electrocardiogram before you start taking this medicine and several times during treatment. This is very important in finding out how the medicine may be affecting your heart. You will need to have blood tests regularly to see how this medicine affects you. Keep all appointments for these tests.

Newborn babies may have trouble breathing or feeding, or other symptoms, if the mother takes this medicine in the last 3 months of pregnancy. This medicine should be used during pregnancy only if the benefit is greater than the possible risk to your baby. Talk with your provider about this.

Contact your healthcare provider if your condition does not improve or if it gets worse.

While taking this medicine, be careful when you exercise, especially when it is hot. This medicine affects your body's ability to cool down, and you may get too hot. If you get too hot, you might vomit, feel dizzy, have a fast heartbeat, get very stiff muscles, or be confused. Contact your provider right away if you have these symptoms.

This medicine may make you drowsy. Do not drive or operate machinery unless you are fully alert.

You may feel dizzy or faint when you get up quickly after sitting or lying down. Getting up slowly may help.

Alcohol may increase the effects of this medicine. Do not drink alcohol while you are taking this medicine without your healthcare provider's approval.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Uncontrollable shaking of your hands or head; uncontrollable puffing of your cheeks, chewing movements, or tongue protrusion (sticking out); seizures; facial swelling; fainting; palpitations; irregular heartbeat; severe muscle stiffness; fever.

Other: Drowsiness, dizziness, dry mouth, constipation, restlessness, blurred vision, trouble urinating, decreased sweating, change in sexual desire or ability.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • antianxiety medicines such as alprazolam (Xanax), clonazepam (Klonopin), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), and oxazepam
  • antibiotics such as azithromycin (Zithromax), ciprofloxacin (Cipro), clarithromycin (Biaxin), erythromycin (Ery-Tabs, E.E.S., Eryc), and pentamidine
  • antidepressants such as amitriptyline, citalopram (Celexa), doxepin, escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine, imipramine (Tofranil), nefazodone, nortriptyline (Pamelor), paroxetine (Paxil), and sertraline (Zoloft),
  • antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), and voriconazole (VFEND)
  • anti-HIV medicines such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Invirase)
  • antimalarials such as chloroquine (Aralen) and mefloquine (Lariam)
  • antinausea medicines such as aprepitant (Emend), dolasetron (Anzemet), droperidol (Inapsine), metoclopramide (Reglan), prochlorperazine and promethazine (Phenergan)
  • antipsychotic medicines such as chlorpromazine, haloperidol (Haldol), olanzapine (Zyprexa), prochlorperazine (Compro), risperidone (Risperdal), thioridazine, trifluoperazine, and ziprasidone (Geodon)
  • dicyclomine (Bentyl)
  • medicines to treat abnormal heartbeat such as amiodarone (Pacerone, Cordarone), disopyramide (Norpace), dofetilide (Tikosyn), procainamide, quinidine, and sotalol (Betapace),
  • narcotic analgesics (pain killers) such as codeine, fentanyl (Duragesic patches), hydrocodone (Vicodin, Lortab), hydromorphone (Dilaudid), meperidine (Demerol), methadone (Dolophine), morphine (MS Contin), oxycodone (OxyContin), oxycodone/acetaminophen (Percocet, Tylox), and pentazocine (Talwin)
  • natural remedies such as gotu kola, kava, St. John's wort, and valerian
  • sedatives such as butabarbital (Butisol), flurazepam, pentobarbital (Nembutal), phenobarbital, temazepam (Restoril), and zolpidem (Ambien)
  • stimulant medicines such as dextroamphetamine (Dexedrine, Adderall), methamphetamine (Desoxyn), and methylphenidate (Ritalin, Concerta, Methylin),
  • tacrolimus (Prograf)
  • zileuton (Zyflo CR)

Do not take this medicine with grapefruit juice because it increases the effects of the medicine.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-10-31
Last reviewed: 2010-04-19
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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