Telephone: 

604-548 6688

Fax: 

604-548 6700

Click here 

for Address & Maps

Language:

Primidone, Oral PRI-mi-done

What are other names for this medicine?

Type of medicine: antiseizure; barbiturate

Generic and brand names: primidone, oral; Mysoline

What is this medicine used for?

This medicine is taken by mouth to control and reduce seizures caused by epilepsy. It may be used for other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergy to any medicines
  • depression or thoughts of suicide
  • kidney or liver disease
  • lung disease
  • porphyria (nerve pain or sensitivity to sunlight)

Females of childbearing age: This medicine is not usually given to pregnant women because it can harm the baby. If you are pregnant, tell your healthcare provider. Do not become pregnant during treatment with this medicine. If you become pregnant, contact your healthcare provider right away. Do not breast-feed while you are receiving this medicine.

How do I use it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes, in regularly spaced doses every day.

You may take this medicine with or without food. Taking it with meals may lessen the chance the drug will upset your stomach. Take it with a full glass of water.

Do not stop taking this medicine without your healthcare provider's approval. You may have to reduce your dosage gradually.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: dizziness, drowsiness, lack of coordination, trouble walking, confusion, cold skin, fever, lightheadedness, fainting, slowed breathing, nausea, vomiting, slurred speech, coma.

What should I watch out for?

Antiseizure medicines may increase suicidal thoughts or actions in some people. Call your healthcare provider right away if you have new or increased thoughts of suicide.

Your healthcare provider will check your progress regularly and adjust your dosage. You will need regular blood tests to see how this medicine affects you. Keep all appointments.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine. Wear some form of identification stating that you take this medicine for epilepsy.

This medicine may make you drowsy or dizzy. Do not drive or operate machinery unless you are fully alert.

This medicine increases the effects of alcohol and other drugs that slow down your nervous system. Do not drink alcohol or take other medicines unless your healthcare provider approves.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Unusual excitement or restlessness, fever, wheezing, vision problems, confusion, worsening of seizures, sore throat, yellowing of the skin or eyes, dark urine, unusual bleeding or bruising, trouble standing or walking, thoughts of suicide.

Other: Drowsiness, dizziness, loss of appetite, nausea, vomiting, change in sex drive.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • alcohol
  • antianxiety medicines such as alprazolam (Xanax), clonazepam (Klonopin), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), and oxazepam
  • antibiotics such as chloramphenicol (Chloromycetin), doxycycline (Adoxa, Doryx, Monodox, Vibramycin), isoniazid, metronidazole (Flagyl), and rifampin (Rifadin, Rimactane)
  • antipsychotic medicines such as chlorpromazine, haloperidol (Haldol), olanzapine (Zyprexa), prochlorperazine (Compro), risperidone (Risperdal), thioridazine, trifluoperazine, and ziprasidone (Geodon)
  • antiseizure medicines such as carbamazepine (Tegretol), ethosuximide (Zarontin), lamotrigine (Lamictal), methsuximide (Celontin), phenobarbital, phenytoin (Dilantin), and valproic acid (Depakene, Depakote)
  • birth control pills, rings, patches, and implants and hormones such as conjugated estrogens (Premarin), estradiol (Estrace), medroxyprogesterone (Provera), and norethindrone (Aygestin, Camila, Jolivette, Micronor)
  • bronchodilators such as aminophylline, dyphylline (Dilex, Lufyllin), and theophylline
  • cimetidine (Tagamet)
  • corticosteroids such as betamethasone (Celestone), cortisone, dexamethasone, fludrocortisone (Florinef), hydrocortisone (Cortef), methylprednisolone (Medrol), prednisolone (Orapred), prednisone, and triamcinolone (Aristospan, Kenalog)
  • doxorubicin (Adriamycin)
  • griseofulvin (Fulvicin, Grifulvin, Gris-Peg, Grisactin)
  • immunosuppressants such as azathioprine (Imuran), cyclosporine (Gengraf, Sandimmune, Neoral), mycophenolate mofetil (CellCept), sirolimus (Rapamune), and tacrolimus (Prograf)
  • MAO inhibitor antidepressants such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam), and tranylcypromine (Parnate) (Do not take this medicine and an MAO inhibitor within 14 days of each other.)
  • natural remedies such as ginkgo biloba, gotu kola, kava, SAMe, St. John's wort, and valerian root
  • quetiapine (Seroquel)
  • warfarin (Coumadin)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-10-13
Last reviewed: 2010-07-15
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
Contact KPJ Penang Specialist Hospital Call: 04-548 66 88 Contact Us Online Request an Appointment