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Quetiapine Fumarate, Oral kwe-TY-a-peen FOO-ma-rate

What are other names for this medicine?

Type of medicine: antipsychotic

Generic and brand names: quetiapine fumarate, oral; Seroquel; Seroquel XR

What is this medicine used for?

This medicine is taken by mouth to treat the symptoms of:

  • bipolar disorder
  • major depression
  • schizophrenia

It may be used for other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • a stroke
  • Alzheimer's disease or dementia
  • cataracts
  • diabetes
  • heart disease
  • high blood pressure
  • high cholesterol
  • liver disease
  • seizures
  • trouble swallowing

Females of childbearing age: Tell your healthcare provider if you are pregnant or become pregnant while taking this medicine. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while you are taking this medicine. Taking this medicine during the last 3 months of pregnancy may cause problems for the baby. Symptoms the baby may have include agitation, tight muscles, floppy muscles, shaking, trouble breathing, or trouble feeding. Talk with your provider about this.

How do I use it?

You will start taking a low dosage. Your dose will gradually be increased until you reach one that works well and causes as few side effects as possible. Follow your healthcare provider's directions exactly.

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes. Do not take more or less or take it longer than prescribed. Do not stop taking this medicine without your healthcare provider's approval. You may have to reduce your dosage gradually.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: extreme drowsiness, fast heartbeat, lightheadedness, fainting, trouble walking, slurred speech.

What should I watch out for?

Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. Call your child's healthcare provider right away if you notice:

  • new or increased thoughts of suicide
  • changes in mood or behavior such as becoming irritable or anxious.

Older adults with dementia are at greater risk for side effects. Talk with your provider about this.

Newborn babies may have trouble breathing or feeding, or other symptoms, if the mother takes this medicine in the last 3 months of pregnancy. This medicine should be used during pregnancy only if the benefit is greater than the possible risk to your baby. Talk with your provider about this.

When you start taking this medicine, you may feel dizzy and faint when you get up too fast from sitting or lying down. This may happen during the first 3 to 5 days you take this medicine or when your dosage is increased. Getting up slowly may help.

Using this medicine for a long time may cause muscle spasms, twitching in the face and body, and uncontrolled tongue or jaw movement. This may happen even after you stop taking the medicine. Talk to your healthcare provider about this.

While taking this medicine, be careful when you exercise, especially when it is hot. This medicine affects your body's ability to cool down, and you may get too hot. If you get too hot, you might vomit, feel dizzy, have a fast heartbeat, get very stiff muscles, or be confused. Contact your provider right away if you have these symptoms.

This medicine may make you drowsy or dizzy. Do not drive or operate machinery until you are fully awake and can see clearly. Also, do not drink alcohol while you are taking this medicine because it may increase these side effects. Ask your healthcare provider about this.

You need to have regular eye exams while on this medicine because it may cause cataracts.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

This medicine may increase the risk of developing diabetes, especially if you are overweight or have a family history of diabetes. If you have diabetes, this medicine may affect your blood sugar level and change the amount of insulin or other diabetes medicines you may need. Talk to your healthcare provider about this.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; severe rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Seizures, tremors, fast or irregular heartbeat, heavy sweating, high fever, muscle stiffness or pain, confusion, feeling as if you need to be moving constantly, muscle spasms, twitching, uncontrolled movements, fainting, thoughts of suicide, increased urination, vision changes.

Other: Headache, drowsiness, dizziness, constipation, dry mouth, upset stomach, changes in vision, weight gain, lightheadedness, stuffy or runny nose.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • antiarrhythmics such as amiodarone (Cordarone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), flecainide (Tambocor), and sotalol (Betapace)
  • antibiotics such as ciprofloxacin (Cipro), clarithromycin (Biaxin), erythromycin (Ery-Tabs, E.E.S.), rifabutin (Mycobutin), and rifampin (Rifadin)
  • antidepressants such as amitriptyline, desipramine (Norpramin), doxepin, fluoxetine (Prozac, Sarafem), imipramine (Tofranil), and nortriptyline (Pamelor)
  • antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral)
  • anti-HIV medicines such as amprenavir, atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), indinavir (Crixivan), ritonavir (Norvir), and saquinavir (Invirase)
  • antiseizure medicines such as carbamazepine (Tegretol), fosphenytoin (Cerebyx), phenobarbital, phenytoin (Dilantin), and primidone
  • beta blockers such as acebutolol (Sectral), atenolol (Tenormin), carvedilol (Coreg), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), pindolol, propranolol (Inderal LA), sotalol (Betapace), and timolol
  • calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiamate, Tiazac), felodipine, isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Procardia, Adalat), and verapamil (Calan, Isoptin, Verelan)
  • cimetidine (Tagamet)
  • corticosteroids such as betamethasone (Entocort EC), cortisone (Cortef), dexamethasone, hydrocortisone, methylprednisolone (Medrol), prednisolone (Prelone, Pediapred), and prednisone
  • donepezil (Aricept)
  • medicines used to treat Parkinson's such as levodopa/carbidopa (Sinemet), pramipexole (Mirapex), ropinirole (Requip), and selegiline (Eldepryl)
  • methadone (Methadose)
  • metoclopramide (Reglan)
  • muscle relaxants such as baclofen (Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), dantrolene (Dantrium), methocarbamol (Robaxin), and tizanidine (Zanaflex)
  • narcotic pain medicines such as codeine, hydrocodone/acetaminophen (Vicodin, Lortab), meperidine (Demerol), morphine (Oramorph, MS Contin), oxycodone (OxyContin, Roxicodone), and oxycodone/acetaminophen (Tylox, Percocet, Endocet)
  • natural remedies such as gotu kola, kava, St. John's wort, and valerian
  • risperidone (Risperdal)
  • rivastigmine (Exelon)
  • sedatives such as butabarbital (Butisol), chloral hydrate, flurazepam, pentobarbital (Nembutal), phenobarbital, temazepam (Restoril), triazolam (Halcion), zaleplon (Sonata), and zolpidem (Ambien)
  • thioridazine
  • tranquilizers such as alprazolam (Xanax), chlordiazepoxide (Librium), diazepam (Valium), and lorazepam (Ativan)

Do not drink alcohol while taking this medicine.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-06-20
Last reviewed: 2010-12-02
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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