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Ranolazine, Oral ra-NOH-la-zeen

What are other names for this medicine?

Type of medicine: antiangina

Generic and brand names: ranolazine, oral; Ranexa

What is this medicine used for?

This medicine is taken by mouth to treat chronic angina (chest pain) when other medicines have not worked. It does not stop angina attacks that have already started. This medicine is usually taken along with other medicines.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • long QT syndrome (problems with electrical activity in the heart muscle)
  • low levels of potassium in the blood
  • kidney or liver disease

Females of childbearing age: Talk with your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as directed by your healthcare provider for the length of time prescribed. Take it regularly every day. Do not change your dosage or stop taking this medicine without your healthcare provider's approval.

These are extended-release tablets, do not break, crush, or chew them. Swallow them whole.

You may take this medicine with or without food. Taking it with meals may lessen the chance the drug will upset your stomach.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: nausea, vomiting, numbness, tingling, dizziness, blurred vision, confusion.

What should I watch out for?

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

This medicine may make you dizzy or drowsy. Do not drive or operate machinery unless you are fully alert.

You may feel dizzy or faint when you get up quickly after sitting or lying down. Getting up slowly may help.

Your healthcare provider will want to see you regularly while you are taking this medicine. Keep all your appointments.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Chest pain; fainting; pounding heartbeat; decreased urination.

Other: Nausea, vomiting, constipation, dry mouth, headache, dizziness, weakness.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • antibiotics such as ciprofloxacin (Cipro), clarithromycin (Biaxin), erythromycin (Ery-Tabs, E.E.S.), isoniazid, levofloxacin (Levaquin), norfloxacin (Noroxin), rifampin (Rifadin, Rimactane), and telithromycin (Ketek)
  • antidepressants such as amitriptyline, doxepin, fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Tofranil), nefazodone, nortriptyline (Pamelor), and paroxetine (Paxil)
  • antifungal medicines such as clotrimazole, fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral)
  • anti-HIV medicines such as delavirdine (Rescriptor), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), and saquinavir (Invirase)
  • antipsychotic medicines such as chlorpromazine, haloperidol (Haldol), olanzapine (Zyprexa), pimozide (Orap), promazine (Sparine), risperidone (Risperdal), thioridazine, trifluoperazine, and ziprasidone (Geodon)
  • antiseizure medicines such as carbamazepine (Tegretol), oxcarbazepine (Trileptal), phenobarbital, phenytoin (Dilantin), and primidone (Mysoline)
  • aprepitant (Emend)
  • arsenic trioxide (Trisenox)
  • cholesterol-lowering medicines (statins) such as atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor)
  • colchicine (Colcrys)
  • cyclosporine (Sandimmune, Neoral, Gengraf)
  • digoxin (Lanoxin)
  • grapefruit juice
  • heart medicines such as amiodarone (Cordarone; Pacerone), diltiazem (Cardizem, Dilacor, Tiamate, Tiazac), disopyramide (Norpace, Norpace CR), dofetilide (Tikosyn), metoprolol (Lopressor), nebivolol (Bystolic), nicardipine (Cardene), procainamide (Procan SR), quinidine, sotalol (Betapace, Betapace AF, Sorine), and verapamil (Calan, Covera, Isoptin)
  • St. John’s wort

Limit how much grapefruit or grapefruit juice you have while taking this medicine. Grapefruit affects the way this medicine works and may increase the risk of side effects.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-06-09
Last reviewed: 2011-06-06
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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