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Rho (D) Immune Globulin, Injection ar-aych-oh dee ih-MYOON GLOB-yoo-lin

What are other names for this medicine?

Type of medicine: immune serum globulin

Generic and brand names: HyperRHO S/D; MICRhoGAM; Rho (D) immune globulin, injection; Rho (D) immune serum globulin, injection; RhoGAM; Rhophylac; Win RhoSDF

What is this medicine used for?

This medicine is given by injection (shot) to prevent an immune response to Rh positive blood in pregnant women with Rh negative blood type. This medicine may also be given to treat a blood disease called idiopathic thrombocytopenic purpura (ITP). Your healthcare provider will explain.

It may be used for other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine or immunization, or to latex
  • bleeding disorders or blood clots
  • diabetes
  • immunoglobulin A deficiency
  • heart attack, stroke, atherosclerosis, or other heart disease
  • high levels of triglycerides in your blood
  • kidney disease
  • myeloma
  • problems with dehydration
  • problems with proteins in the blood
  • surgery to remove your spleen

Tell your healthcare provider if you have recently had a long period of bed rest or such as after major surgery or a broken bone in a cast.

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while receiving this medicine without your healthcare provider's approval.

How do I use it?

These injections are given by your healthcare provider. They may be given while you are in a hospital or clinic.

You may need to have more than one injection over a period of time. Be sure to have the recommended number of shots on schedule.

What should I watch out for?

You may feel tenderness, pain, or muscle stiffness where you had the shot. Contact your healthcare provider if these symptoms do not improve after several hours.

You will need to have lab tests regularly to see how this medicine affects you. Keep all appointments for these tests.

This medicine is made from human tissue. It is tested for viruses such as hepatitis and HIV. The risk of getting an infection from this medicine is very low, but it is still possible. Talk with your healthcare provider about this.

This medicine may interfere with your response to live-virus vaccines (for several months after you receive this medicine. Talk with your healthcare provider about this. Do not have any vaccines without getting your healthcare provider's approval first.

This medicine may cause a severe, life-threatening reaction in people with idiopathic thrombocytopenic purpura (ITP). You will be closely monitored for at least 8 hours after you receive this medicine. If you have back pain, dark or discolored (such as pink) urine, fever, chills, shaking, urinating less often, sudden weight gain, explained swelling, and shortness of breath, contact your healthcare provider right away.

Adults over the age of 65 may be at greater risk for side effects. Talk with your healthcare provider about this.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you have received this medicine.

Diabetics: This medicine may affect blood sugar test results. Talk to your healthcare provider before you change your diet or dosage of diabetes medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you are unable to reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; fever; chills; nausea; vomiting; chest tightness; trouble breathing; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Unusual bleeding or bruising; rapid heart rate; fainting; severe back pain; severe shaking chills; fever; unusual urine color (such as pink); dark urine; severe nausea or vomiting; problems urinating or urinating less often; swelling in hands, ankles, or feet; shortness of breath; sudden weight gain; numbness or weakness, especially on one side of your body; trouble talking or walking; unexplained leg pain or swelling.

Other: Tenderness, pain, or redness where the shot was given; headache; joint or muscle pain; tiredness; flushing; sweating; stomach cramps; nausea; vomiting; diarrhea; dizziness; itching; rash; mild fever.

What products might interact with this medicine?

Many other medicines may cause kidney problems. Tell your healthcare provider about all the medicines you take, including over-the-counter medicines.

Check with your healthcare provider before having any live-virus vaccinations (such as shots for measles, mumps, and rubella). This medicine may interfere with your response to vaccines for up to 6 months or longer after receiving this medicine.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-10-04
Last reviewed: 2011-08-02
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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