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Ropinirole Hydrochloride, Oral roh-PIN-ih-role hy-droh-KLOR-ide

What are other names for this medicine?

Type of medicine: anti-Parkinson's

Generic and brand names: ropinirole hydrochloride, oral; Requip; Requip XL

What is this medicine used for?

This medicine is taken by mouth to treat the symptoms of Parkinson's disease. It is also used to treat restless legs syndrome.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • a sleep disorder such as sleep apnea or narcolepsy
  • hallucinations
  • heart disease
  • liver disease
  • low blood pressure

Tell your healthcare provider if you smoke cigarettes. It can change how this medicine works.

Females of childbearing age: Talk with your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Check the label on the medicine for directions about your specific dose. Your healthcare provider may change your dosage until you reach one that works well and causes as few side effects as possible. Take this medicine exactly as your healthcare provider prescribes. Do not take more or less than prescribed. Do not stop taking this medicine without your healthcare provider's approval. You need to reduce your dosage gradually.

This medicine comes in regular or sustained-release forms. Do not crush or chew sustained release tablets. If you do not know which product you have, check with your pharmacist.

You may take this medicine with or without food. Taking it with meals may lessen the chance the drug will upset your stomach.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: dizziness, lightheadedness, nausea, vomiting, weakness, fainting, restlessness, confusion, hallucinations, muscle twitching, tingling, chest pain.

What should I watch out for?

This medicine may cause you to fall asleep without warning during daily activities including driving a car. If you have drowsiness that continues or becomes severe, you may need to stop taking this medicine. Do not drive or operate machinery if you feel the least bit drowsy or dizzy. These reactions may become more severe if you drink alcohol or take sedatives (narcotics, muscle relaxants or some allergy medicines) while you are taking this medicine. Talk to your healthcare provider about this.

Adults over the age of 65 have a greater risk for hallucinations (seeing and hearing things that are not there).

You may become dizzy or nauseous, sweat heavily, or pass out if you get up too quickly from sitting or lying down. This may happen more often when you first start taking this medicine. Getting up slowly may help.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

Tell your provider if your symptoms get worse or come back between doses.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Feeling dizzy most of the time; fainting; high fever; rigid muscles; severe confusion; chest pain; swelling in the feet; ankles; or legs; vision changes; falling asleep without warning; abnormal movements of the body; trouble urinating; painful urination; hallucinations; unusual urges or behavior; very fast or slow heartbeat.

Other: Tiredness, weakness, dry mouth, trouble sleeping, nausea, vomiting, headache, dizziness, drowsiness, abnormal dreams, constipation, diarrhea, heavy sweating, muscle or joint pain.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • alcohol
  • antianxiety medicines such as alprazolam (Xanax), clonazepam (Klonopin), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), and oxazepam
  • antiarrhythmics (medicines to treat irregular heartbeat) such as amiodarone (Cordarone, Pacerone) and quinidine
  • antibiotics such as ciprofloxacin (Cipro), erythromycin (Ery-Tabs, E.E.S.), gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), and ofloxacin (Floxin)
  • antidepressants such as amitriptyline, bupropion (Wellbutrin), doxepin, duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox CR), imipramine (Tofranil), nefazodone, nortriptyline (Pamelor), paroxetine (Paxil), sertraline (Zoloft), trazodone, and venlafaxine (Effexor)
  • antihistamines such as chlorpheniramine (Chlor-Trimeton), diphenhydramine (Benadryl), hydroxyzine (Vistaril), and meclizine (Antivert, Dramamine)
  • anti-HIV medicines such as delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), saquinavir (Invirase), and stavudine (Zerit)
  • antipsychotic medicines such as chlorpromazine, haloperidol (Haldol), olanzapine (Zyprexa), prochlorperazine (Compro), risperidone (Risperdal), thioridazine, trifluoperazine, and ziprasidone (Geodon)
  • birth control pills, rings, patches, and implants and hormones such as conjugated estrogens (Premarin), estradiol (Estrace), medroxyprogesterone (Provera), and norethindrone (Aygestin, Camila, Jolivette, Micronor)
  • cimetidine (Tagamet)
  • levodopa/carbidopa (Sinemet)
  • MAO inhibitor antidepressants such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam), and tranylcypromine (Parnate) (Do not take this medicine and an MAO inhibitor within 14 days of each other.)
  • metoclopramide (Reglan)
  • muscle relaxants such as baclofen (Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), dantrolene (Dantrium), methocarbamol (Robaxin), and tizanidine (Zanaflex)
  • narcotic analgesics (painkillers) such as codeine, fentanyl (Duragesic, Actiq), hydrocodone (Vicodin, Lortab), meperidine (Demerol), morphine, oxycodone (OxyContin), oxycodone/acetaminophen (Percocet, Tylox), and pentazocine (Talwin)
  • natural remedies such as gotu kola, kava, St. John's Wort, and valerian
  • promethazine (Phenergan)
  • sleeping pills such as amobarbital (Amytal), butabarbital (Butisol), flurazepam, phenobarbital, temazepam (Restoril), triazolam (Halcion), zaleplon (Sonata), and zolpidem (Ambien)
  • warfarin (Coumadin)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-07-15
Last reviewed: 2010-07-15
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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