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Tacrine Hydrochloride, Oral TAK-reen hy-droh-KLOR-ide

What are other names for this medicine?

Type of medicine: acetylcholinesterase inhibitor

Generic and brand names: tacrine hydrochloride, oral; Cognex

What is this medicine used for?

This medicine is taken by mouth to treat symptoms of Alzheimer's-type dementia.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • asthma or other breathing problems
  • liver disease
  • kidney disease
  • heart disease, an irregular heartbeat, or a heart attack
  • Parkinson's disease
  • seizures
  • stomach ulcers
  • loss of appetite or unintended weight loss
  • trouble urinating

Females of childbearing age: Talk with your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes. Your provider may adjust the dosage to find the one that is best. Do not take more or less or take it longer than prescribed. Do not stop taking this medicine without your healthcare provider's approval. Changing your dosage may cause a serious decline in your ability to think and control your behavior.

Take this medicine on an empty stomach. If the medicine causes stomach upset, you may take it with meals. Follow your healthcare provider's directions exactly.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: severe nausea or vomiting, drooling, sweating, slow heartbeat, small pupils, wheezing or trouble breathing, lightheadedness, fainting, muscle weakness, seizures, coma.

What should I watch out for?

This medicine may cause urinary problems. If you have trouble urinating, contact your healthcare provider right away.

You will need to have blood tests regularly to see how this medicine affects your liver. Keep all appointments for these tests.

You may feel dizzy or faint when you get up quickly after sitting or lying down. Getting up slowly may help.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

Smoking tobacco may lower the blood levels of this medicine. If you smoke, your healthcare provider may need to change the dosage of your medicine.

People who have Alzheimer's disease should not be allowed to drive, operate machinery, or perform other hazardous tasks. This medicine may cause dizziness and confusion, which can add to the problems caused by the disease itself.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Seizures, chest pain, yellowing of skin or eyes, changes in stool color (black or light color), fast or irregular heartbeat, trouble urinating, severe nausea or vomiting, extreme weakness.

Other: Nausea, vomiting, loose stools, diarrhea, headache, dizziness, confusion, drowsiness, poor appetite, muscle pain, anxiety, trouble sleeping.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • alcohol
  • anticholinergic medicines such as amantadine (Symmetrel), atropine sulfate, belladonna, benztropine (Cogentin), biperiden (Akineton), dicyclomine (Bentyl), hyoscyamine (Levsin, Levsinex), methscopolamine (Pamine), procyclidine (Kemadrin), propantheline (Pro-Banthine), and trihexyphenidyl (Artane)
  • cholinergic medicines such as bethanechol (Urecholine), neostigmine (Prostigmin), and pyridostigmine (Mestinon)
  • nicotine (smoking) and nicotine replacement medicines such as NicoDerm, Nicotrol, and Nicorette
  • fluvoxamine (Luvox)
  • haloperidol (Haldol)
  • levodopa/carbidopa (Sinemet)
  • NSAIDs such as diclofenac (Voltaren, Cataflam), ibuprofen (Motrin, Motrin IB, Advil), indomethacin (Indocin), ketoprofen, ketorolac (Toradol), nabumetone (Relafen), naproxen (Naprosyn, Anaprox, Aleve, Naprelan), oxaprozin (Daypro), piroxicam (Feldene), and sulindac (Clinoril)
  • other medicines to treat Alzheimer's disease such as donepezil (Aricept) and galantamine (Razadyne)
  • riluzole (Rilutek)
  • theophylline and aminophylline

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2010-07-11
Last reviewed: 2010-03-15
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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