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Tiagabine Hydrochloride, Oral ty-AG-a-been

What are other names for this medicine?

Type of medicine: antiseizure

Generic and brand names: tiagabine hydrochloride, oral; Gabitril

What is this medicine used for?

This medicine is taken by mouth to treat partial seizures. This medicine is usually taken with other medicines.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • depression, mood problems, or suicidal thoughts or behavior
  • seizures that do not stop (status epilepticus)
  • liver disease

Females of childbearing age: Talk with your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Read the Medication Guide that comes in the medicine package when you start taking this medicine and each time you get a refill.

Check the label on the medicine for directions about your specific dose. At first, you will take a low dose of this medicine once a day. Your provider will increase your dosage gradually over a period of weeks until you reach a dosage that reduces or eliminates your seizures. Higher daily dosages are usually divided into 2 to 4 doses a day. Be sure you understand when to take this medicine and how much to take.

Do not stop taking this medicine without your healthcare provider's approval. You may have to gradually reduce your dosage. Seizures may get worse if you suddenly stop taking this medicine.

Take this medicine with food or milk.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: slurred speech, weakness, drowsiness, muscle stiffness, problems with coordination, confusion, vomiting, weak or shallow breathing, increased seizures, or feeling hostile or agitated.

What should I watch out for?

Antiseizure medicines may increase suicidal thoughts or actions in some people. Call your healthcare provider right away if you or your family notices any disturbing changes in your thoughts or behavior, such as: more outgoing or aggressive behavior than normal, confusion, hallucinations, worsening of depression, or suicidal thoughts.

This medicine may make you sleepy, dizzy, or depressed. Do not drive or operate machinery until you are fully alert and can think clearly.

Alcohol and other medicines that slow down your nervous system may add to your side effects. Do not drink alcohol while you are taking this medicine without your healthcare provider's approval.

Do not share this medicine with others. This medicine may cause seizures that do not stop in people who do not have a seizure disorder.

You may need to have blood tests regularly to see how this medicine affects you. Keep all appointments for these tests.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine. Carry some form of identification stating that you have seizures and are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your health care provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Increase in the number of seizures, unusual weakness, severe confusion, fainting, vision changes, blistering or peeling skin, new or worsening depression, thought of suicide, unusual mood or behavior changes.

Other: Dizziness, drowsiness, nervousness, trouble concentrating, trouble talking, nausea, vomiting, diarrhea, trouble sleeping, stomach pain, tremors.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • antianxiety medicines such as alprazolam (Xanax), chlordiazepoxide (Librium), diazepam (Valium), lorazepam (Ativan), midazolam (Versed), and triazolam (Halcion)
  • antibiotics such as clarithromycin (Biaxin, Biaxin XL), erythromycin (Ery-Tabs, E.E.S.), isoniazid, and rifampin (Rifadin, Rimactane)
  • antidepressants such as bupropion (Wellbutrin, Zyban), citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), nefazodone, paroxetine (Paxil), and sertraline (Zoloft)
  • antifungal medicines such as itraconazole (Sporanox) and ketoconazole (Nizoral)
  • antihistamines such as chlorpheniramine (Chlor-Trimeton), diphenhydramine (Benadryl), hydroxyzine (Vistaril), and meclizine (Antivert, Dramamine)
  • anti-HIV medicines such as delavirdine (Rescriptor), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), and saquinavir (Invirase)
  • antinausea medicines such as prochlorperazine and promethazine (Phenergan)
  • antipsychotic medicines such as chlorpromazine, fluphenazine, haloperidol (Haldol), olanzapine (Zyprexa), perphenazine, risperidone (Risperdal), thioridazine, trifluoperazine, and ziprasidone (Geodon)
  • antiseizure medicines such as carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), primidone (Mysoline), and valproic acid (Depakene, Depakote, Depacon)
  • imatinib (Gleevec)
  • muscle relaxants such as baclofen (Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), dantrolene (Dantrium), methocarbamol (Robaxin), and tizanidine (Zanaflex)
  • narcotic pain medicines such as codeine, fentanyl (Duragesic, Actiq), hydromorphone (Dilaudid), meperidine (Demerol), morphine, and oxycodone (Roxicodone, OxyContin)
  • natural remedies such as ginkgo, gotu kola, kava, St. John's wort, and valerian
  • sleeping pills such as chloral hydrate, eszopiclone (Lunesta), zaleplon (Sonata), and zolpidem (Ambien)
  • stimulant medicine such as dexmethylphenidate (Focalin, Focalin XR) and methylphenidate (Concerta, Metadate CD, Metadate ER, Ritalin)

Do not drink alcohol while you are taking this medicine.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-06-30
Last reviewed: 2011-02-28
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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