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Tizanidine Hydrochloride, Oral ty-ZAN-i-deen hy-droh-KLOR-ide

What are other names for this medicine?

Type of medicine: skeletal muscle relaxant

Generic and brand names: tizanidine hydrochloride, oral; Zanaflex

What is this medicine used for?

This medicine is used to relax your muscles to relieve pain from spasms.

It may be used for other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • heart disease or a fast or irregular heartbeat
  • high or low blood pressure
  • kidney or liver problems

Do not take this medicine with fluvoxamine (Luvox CR) or ciprofloxacin (Cipro) due to an increased risk of side effects.

Females of childbearing age: Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider's approval.

How do I take it?

Take this medicine exactly as your healthcare provider prescribes. Check the label on the medicine for directions about your specific dose. Do not take more or take it more often than directed. Your healthcare provider will adjust your dosage depending on how the medicine works for you.

Do not stop taking this medicine without your healthcare provider's approval. Some conditions may become worse when the drug is suddenly stopped. Your dose must be gradually decreased to avoid side effects.

This medicine is available in capsules and tablets. The capsules are NOT the same as the tablets. Do not switch between capsules and tablets unless your healthcare provider approves.

You may take this medicine with or without food, but you should always take it the same way. Follow your healthcare provider's instructions as to whether to take this medicine with or without food.

If you have trouble swallowing the capsules or tablets, talk with your healthcare provider. Do NOT open the capsules unless your healthcare provider tells you to do so.

You may take this medicine with or without food. Taking it with meals may lessen the chance the drug will upset your stomach.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: coma, confusion, drowsiness, fainting, lightheadedness, shallow breathing, slow heartbeat.

What should I watch out for?

This medicine may make you feel dizzy or faint, especially when you get up from sitting or lying down. Getting up slowly may help. If you get dizzy or drowsy, do not drive or operate machinery until you are fully alert.

This medicine may cause dry mouth. Use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. If dry mouth lasts longer than 2 weeks, tell your healthcare provider about it.

Adults over the age of 65 may be at greater risk for side effects. Talk with your healthcare provider about this.

This medicine increases the effects of alcohol and other drugs that slow down your nervous system. Do not drink alcohol or take other medicines unless your healthcare provider approves.

Contact your healthcare provider if your condition does not improve or if it gets worse.

Your healthcare provider may want to see you regularly to see how this medicine affects you. Keep all appointments.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Yellowing of skin or eyes; loss of appetite; fainting; unexplained fever; pain while urinating; dark urine; hallucinations; unusual tiredness; hallucinations; unusual thoughts or behavior.

Other: Dry mouth, drowsiness, dizziness, constipation, back pain, sweating, nervousness, diarrhea, trouble sleeping, trouble walking, weakness.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • alcohol
  • antifungal medicines such as fluconazole (Diflucan) and ketoconazole (Nizoral)
  • antihistamines such as brompheniramine, chlorpheniramine (Chlor-Trimeton), clemastine (Tavist-1), dexchlorpheniramine (Polaramine), and diphenhydramine (Benadryl)
  • barbiturates such as butabarbital (Butisol), pentobarbital (Nembutal), and phenobarbital
  • ACE inhibitors such as benazepril (Lotensin), captopril, enalapril (Vasotec), fosinopril, lisinopril (Prinivil, Zestril), quinapril (Accupril), and ramipril (Altace)
  • acyclovir (Zovirax)
  • antibiotics such as ciprofloxacin (Cipro), gemifloxacin (Factive), levofloxacin (Levaquin), lomefloxacin (Maxaquin), norfloxacin (Noroxin), and ofloxacin (Floxin)
  • beta blockers such as acebutolol (Sectral), atenolol (Tenormin), carvedilol (Coreg), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), pindolol, propranolol (Inderal LA), and sotalol (Betapace)
  • birth control pills
  • calcium channel blockers such as diltiazem (Cardizem, felodipine, isradipine (DynaCirc CR), nicardipine (Cardene), nifedipine (Adalat CC, Procardia), and verapamil (Calan, Covera-HS, Isoptin SR, Verelan, Tiazac)
  • diuretics such as furosemide (Lasix) and hydrochlorothiazide
  • fluvoxamine (Luvox)
  • heart medicines such as amiodarone (Cordarone, Pacerone), mexiletine (Mexitil), propafenone (Rythmol), and verapamil (Calan, Covera, Isoptin)
  • heartburn medicines such as cimetidine (Tagamet) and famotidine (Pepcid)
  • natural remedies such as gotu kola, kava, St. John's wort, and valerian
  • other muscle relaxants such as baclofen (Gablofen, Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), dantrolene (Dantrium), methocarbamol (Robaxin), and tizanidine (Zanaflex)
  • pain medicines such as codeine, fentanyl (Duragesic, Actiq), hydrocodone/acetaminophen (Vicodin), hydromorphone (Dilaudid), meperidine (Demerol), morphine (Kadian, MS Contin), oxycodone (Roxicodone, OxyContin), oxycodone/acetaminophen (Percocet, Tylox), pentazocine (Talwin), and tramadol (Ultram)
  • phenothiazines such as chlorpromazine, fluphenazine, prochlorperazine, and thioridazine
  • sleeping pills such as amobarbital (Amytal), butabarbital (Butisol), flurazepam, temazepam (Restoril), triazolam (Halcion), zaleplon (Sonata), and zolpidem (Ambien)
  • zileuton (Zyflo)
  • tranquilizers such as alprazolam (Xanax), chlordiazepoxide (Librium), diazepam (Valium), and lorazepam (Ativan)

Do not drink alcohol while you are taking this medicine.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-07-15
Last reviewed: 2010-10-07
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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