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Triptorelin Pamoate, Injection trip-toh-REL-in PAM-oh-ate

What are other names for this medicine?

Type of medicine: antineoplastic (anticancer)

Generic and brand names: triptorelin pamoate, injection; Trelstar Depot; Trelstar LA

What is this medicine used for?

This medicine is given by injection (shot) to treat advanced prostate cancer. It may be used instead of surgery or estrogen treatment. It may also be used for other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergy to any medicine
  • a stroke or heart attack
  • cancer in your spine
  • diabetes
  • heart disease
  • high blood pressure
  • high cholesterol
  • liver or kidney disease
  • trouble urinating

Tell your provider if you smoke cigarettes.

This medicine must not be used by women who are pregnant or may become pregnant. This medicine has been reported to cause birth defects.

How do I use it?

These shots are given by a healthcare provider. This is a slow-release medicine that will last several weeks. The shots are given into a muscle. Keep all appointments for shots.

What should I watch out for?

During the first weeks of treatment the signs and symptoms of prostate cancer may get worse. If you have bone pain or neuropathy (numbness and pain in your feet or hands), are unable to urinate, or notice blood in your urine, contact your healthcare provider right away.

This medicine may increase your risk for a heart attack or stroke. Contact your healthcare provider right away if you have dizziness, lightheadedness, fainting, or abnormal heartbeats.

You will need to have blood tests to check how well you are responding to this medicine. Keep all appointments for tests.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you have received this medicine.

You may develop diabetes when you take this medicine. If you already have diabetes, it may get worse. Talk with your healthcare provider about this.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report to your healthcare provider right away): Bone pain, numbness and pain in your feet or hands, trouble urinating or pain while urinating, blood in the urine, unusual weakness, sudden headache, unexplained swelling.

Other: Hot flashes, headache, change in sexual ability or desire, injection site pain, lightheadedness, dizziness, trouble sleeping, nausea, vomiting, diarrhea, breast pain or swelling.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • antipsychotic medicines such as chlorpromazine, fluphenazine, haloperidol (Haldol), olanzapine (Zyprexa), perphenazine, prochlorperazine, promazine (Sparine), risperidone (Risperdal), thioridazine, and trifluoperazine
  • cimetidine (Tagamet)
  • estrogen or testosterone
  • methyldopa
  • metoclopramide (Reglan)
  • reserpine
  • natural remedies such as black cohosh, chasteberry, and DHEA

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.


This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.


Developed by RelayHealth.
Medication Advisor 2012.1 published by RelayHealth.
Last modified: 2011-06-29
Last reviewed: 2010-06-24
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.
© 2012 RelayHealth and/or its affiliates. All rights reserved.
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